Molecular Evolution of Lycopene Cyclases Involved in the Formation of Carotenoids in Eukaryotic Algae
Cui, Hongli1,2; Wang, Yinchu1,2; Qin, Song1
发表期刊PLANT MOLECULAR BIOLOGY REPORTER
ISSN0735-9640
2011-12-01
卷号29期号:4页码:1013-1020
关键词Carotenoid Biosynthesis Lycopene Cyclase Molecular Evolution Coevolution Algae
产权排序[Cui, Hongli; Wang, Yinchu; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Cui, Hongli; Wang, Yinchu] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
通讯作者Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
作者部门生物资源实验室 
英文摘要Carotenoids play crucial roles in structure and function of the photosynthetic apparatus of bacteria, algae, and higher plants. The formation of carotenoids from lycopene is catalyzed by the enzyme lycopene cyclase (LCY), which is structurally and functionally conserved in all organisms. A comparative genomic analysis regarding the LCY revealed that the higher plant (Arabidopsis thaliana) and the green alga (Ostreococcus sp. RCC809, Ostreococcus tauri, Ostreococcus lucimarinus, Micromonas sp. RCC299, Micromonas pusiua, Chlorella vulgaris, Volvox carteri, and Coccomyxa sp. C-169) possess two different LCY (beta- and epsilon-type). This indicated that an ancient gene duplication event must have occurred, which produced two classes of LCY in algae. However, some other green alga retained only one class of LCY, such as Haematococcus pluvialis (beta), Dunaliella salina (beta), Chlamydomonas reinhardtii (epsilon), and Chlorella sp. NC64A (epsilon), and the other gene copy was lost in these species. Furthermore, the similar LCY lost occurred in red alga (Cyanidioschyzon merolae) and Heterokontophyta (Phaeodactylum tricornutum and Thalassiosira pseudonana), which possess only the LCYB. In addition, the protein sequence of LCYB is highly similar to capsanthin-capsorubin synthase (CCS), which is another carotenogenic enzyme of plants. As a result, it is proposed that the CCS evolved from a duplicated LCYB. The discovery of two classes of LCY families in some algae suggests that carotenoid biosynthesis is differentially regulated in response to development and environmental stress in these algae, like members of LCY families are differentially regulated during development or stress in some higher plants.; Carotenoids play crucial roles in structure and function of the photosynthetic apparatus of bacteria, algae, and higher plants. The formation of carotenoids from lycopene is catalyzed by the enzyme lycopene cyclase (LCY), which is structurally and functionally conserved in all organisms. A comparative genomic analysis regarding the LCY revealed that the higher plant (Arabidopsis thaliana) and the green alga (Ostreococcus sp. RCC809, Ostreococcus tauri, Ostreococcus lucimarinus, Micromonas sp. RCC299, Micromonas pusiua, Chlorella vulgaris, Volvox carteri, and Coccomyxa sp. C-169) possess two different LCY (beta- and epsilon-type). This indicated that an ancient gene duplication event must have occurred, which produced two classes of LCY in algae. However, some other green alga retained only one class of LCY, such as Haematococcus pluvialis (beta), Dunaliella salina (beta), Chlamydomonas reinhardtii (epsilon), and Chlorella sp. NC64A (epsilon), and the other gene copy was lost in these species. Furthermore, the similar LCY lost occurred in red alga (Cyanidioschyzon merolae) and Heterokontophyta (Phaeodactylum tricornutum and Thalassiosira pseudonana), which possess only the LCYB. In addition, the protein sequence of LCYB is highly similar to capsanthin-capsorubin synthase (CCS), which is another carotenogenic enzyme of plants. As a result, it is proposed that the CCS evolved from a duplicated LCYB. The discovery of two classes of LCY families in some algae suggests that carotenoid biosynthesis is differentially regulated in response to development and environmental stress in these algae, like members of LCY families are differentially regulated during development or stress in some higher plants.
文章类型Article
资助机构National Natural Science Foundation of China[40876082]; International Innovation Partnership Program: Typical Environmental Process and Effects on Resources in Coastal Zone Area
收录类别SCI
语种英语
关键词[WOS]FUNCTIONAL-ANALYSIS ; GENE-TRANSFER ; ISOPRENOID BIOSYNTHESIS ; PHYTOENE SYNTHASE ; CRT GENES ; PLANTS ; PATHWAY ; PHYLOGENIES ; ENZYMES ; CLONING
研究领域[WOS]Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000296068700027
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/5354
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Cui, Hongli,Wang, Yinchu,Qin, Song. Molecular Evolution of Lycopene Cyclases Involved in the Formation of Carotenoids in Eukaryotic Algae[J]. PLANT MOLECULAR BIOLOGY REPORTER,2011,29(4):1013-1020.
APA Cui, Hongli,Wang, Yinchu,&Qin, Song.(2011).Molecular Evolution of Lycopene Cyclases Involved in the Formation of Carotenoids in Eukaryotic Algae.PLANT MOLECULAR BIOLOGY REPORTER,29(4),1013-1020.
MLA Cui, Hongli,et al."Molecular Evolution of Lycopene Cyclases Involved in the Formation of Carotenoids in Eukaryotic Algae".PLANT MOLECULAR BIOLOGY REPORTER 29.4(2011):1013-1020.
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