Asporyergosterol, A New Steroid from an Algicolous Isolate of Aspergillus oryzae
Qiao, Ming-Feng1,2; Ji, Nai-Yun1; Liu, Xiang-Hong1; Li, Fang3; Xue, Qin-Zhao1
Source PublicationNATURAL PRODUCT COMMUNICATIONS
ISSN1934-578X
2010-10-01
Volume5Issue:10Pages:1575-1578
KeywordAsporyergosterol Red Alga Heterosiphonia Japonica Endophytic Fungus Aspergillus Oryzae
Contribution Rank[Qiao, Ming-Feng; Ji, Nai-Yun; Liu, Xiang-Hong; Xue, Qin-Zhao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Qiao, Ming-Feng] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; [Li, Fang] Qingdao Univ Sci & Technol, Qingdao 266042, Peoples R China
Corresponding AuthorJi, NY, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
Department生物资源实验室 
AbstractAsporyergosterol (1), a new steroid with an E double bond between C-17 and C-20, was identified from the culture extracts of Aspergillus oryzae, an endophytic fungus isolated from the marine red alga Heterosiphonia japonica. Moreover, four known steroids including (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (2), (22E,24R)-3 beta-hydroxyergosta-5,8,22-trien-7-one (3), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (4), and (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (5) were isolated. Structures of these compounds were unambiguously established by spectroscopic techniques and by comparison with literature values. All the isolates exhibited low activity to modulate acetylcholinesterase (AChE).; Asporyergosterol (1), a new steroid with an E double bond between C-17 and C-20, was identified from the culture extracts of Aspergillus oryzae, an endophytic fungus isolated from the marine red alga Heterosiphonia japonica. Moreover, four known steroids including (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (2), (22E,24R)-3 beta-hydroxyergosta-5,8,22-trien-7-one (3), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (4), and (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (5) were isolated. Structures of these compounds were unambiguously established by spectroscopic techniques and by comparison with literature values. All the isolates exhibited low activity to modulate acetylcholinesterase (AChE).
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordFUNGI
WOS Research AreaPharmacology & Pharmacy ; Food Science & Technology
WOS IDWOS:000283380800012
Funding OrganizationChinese Academy of Sciences for Key Topics in Innovation Engineering [KZCX2-YW-QN209, KSCX2-YW-G-073, KZCX2-YW-225]; Shandong Province Natural Science Foundation [ZR2009BQ021]; Yantai Municipal Sci-Tech Development Program [2009164]; Foundation of the Chinese Academy of Sciences
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Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/3745
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Qingdao Univ Sci & Technol, Qingdao 266042, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Ming-Feng,Ji, Nai-Yun,Liu, Xiang-Hong,et al. Asporyergosterol, A New Steroid from an Algicolous Isolate of Aspergillus oryzae[J]. NATURAL PRODUCT COMMUNICATIONS,2010,5(10):1575-1578.
APA Qiao, Ming-Feng,Ji, Nai-Yun,Liu, Xiang-Hong,Li, Fang,&Xue, Qin-Zhao.(2010).Asporyergosterol, A New Steroid from an Algicolous Isolate of Aspergillus oryzae.NATURAL PRODUCT COMMUNICATIONS,5(10),1575-1578.
MLA Qiao, Ming-Feng,et al."Asporyergosterol, A New Steroid from an Algicolous Isolate of Aspergillus oryzae".NATURAL PRODUCT COMMUNICATIONS 5.10(2010):1575-1578.
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