Advances in peptide-based drug delivery systems

doi:10.1016/j.heliyon.2024.e26009

	Advances in peptide-based drug delivery systems
	Guo, Sijie 1,2; Wang, Jing 2; Wang, Qi 1,2; Wang, Jinxin 3; Qin, Song2 ; Li, Wenjun1,2
发表期刊	HELIYON
	2024-02-29
卷号	10 期号:4 页码:21
关键词	Functional peptide Drug delivery system Peptide -drug coupling Application prospects
DOI	10.1016/j.heliyon.2024.e26009
通讯作者	Li, Wenjun(wjli@yic.ac.cn)
英文摘要	Drug delivery systems (DDSs) are designed to deliver drugs to their specific targets to minimize their toxic effects and improve their susceptibility to clearance during targeted transport. Peptides have high affinity, low immunogenicity, simple amino acid composition, and adjustable molecular size; therefore, most peptides can be coupled to drugs via linkers to form peptide-drug conjugates (PDCs) and act as active pro-drugs. PDCs are widely thought to be promising DDSs, given their ability to improve drug bio-compatibility and physiological stability. Peptide-based DDSs are often used to deliver therapeutic substances such as anti-cancer drugs and nucleic acid-based drugs, which not only slow the degradation rate of drugs in vivo but also ensure the drug concentration at the targeted site and prolong the half-life of drugs in vivo. This article provides an profile of the advancements and future development in functional peptide-based DDSs both domestically and internationally in recent years, in the expectation of achieving targeted drug delivery incorporating functional peptides and taking full advantage of synergistic effects.
资助机构	National Key Research and Development Program of China ; Jilin Province ; Chinese Academy of Sciences ; Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast
收录类别	SCI
语种	英语
关键词[WOS]	CELL-PENETRATING PEPTIDES ; TUMOR-ASSOCIATED MACROPHAGES ; HOMING PEPTIDES ; POLYPEPTIDE NANOPARTICLES ; TARGETED DELIVERY ; CANCER-THERAPY ; PLASMID DNA ; IN-SITU ; MICROENVIRONMENT ; OVARIAN
研究领域[WOS]	Science & Technology - Other Topics
WOS记录号	WOS:001198253500001
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35317
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Li, Wenjun
作者单位	1.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao 266112, Shandong, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 3.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Guo, Sijie,Wang, Jing,Wang, Qi,et al. Advances in peptide-based drug delivery systems[J]. HELIYON,2024,10(4):21.
APA	Guo, Sijie,Wang, Jing,Wang, Qi,Wang, Jinxin,Qin, Song,&Li, Wenjun.(2024).Advances in peptide-based drug delivery systems.HELIYON,10(4),21.
MLA	Guo, Sijie,et al."Advances in peptide-based drug delivery systems".HELIYON 10.4(2024):21.