| Anlotinib enhances the antitumor immunity of radiotherapy by activating cGAS | |
| Dong Han1; Jiajia Zhang2; Yawei Bao3; Lei Liu3; Ping Wang1; Dong Qian3 | |
| 发表期刊 | CELL DEATH DISCOVERY
 |
| ISSN | 2058-7716 |
| 2022 | |
| 卷号 | 8期号:1 |
| 英文摘要 | Radiation resistance and unsatisfactory efficacy of radioimmunotherapy are important barriers to non-small cell lung cancer (NSCLC) treatment. The impacts of anlotinib on radiation and tumor immune microenvironment (TIME) in NSCLC remain to be resolved. Here, we find anlotinib enhances radiosensitivity, and further increases radiotherapy-stimulated CD8 + T cell infiltration and activation via triggering cGAS + T cell exhaustion, promotes the cytotoxicity and proliferation of CD8 + T cells, and boosts immune memory activation. Our work reveals the crucial role of anlotinib in antitumor immunity, and provides preclinical evidence for the application of anlotinib combined with radioimmunotherapy in NSCLC treatment. |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/34565 |
| 专题 | 中国科学院烟台海岸带研究所 |
| 作者单位 | 1.Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Immunology and Biotherapy 2.中国科学院烟台海岸带研究所 3.中国科学技术大学 |
| 推荐引用方式 GB/T 7714 | Dong Han,Jiajia Zhang,Yawei Bao,et al. Anlotinib enhances the antitumor immunity of radiotherapy by activating cGAS[J]. CELL DEATH DISCOVERY,2022,8(1). |
| APA | Dong Han,Jiajia Zhang,Yawei Bao,Lei Liu,Ping Wang,&Dong Qian.(2022).Anlotinib enhances the antitumor immunity of radiotherapy by activating cGAS.CELL DEATH DISCOVERY,8(1). |
| MLA | Dong Han,et al."Anlotinib enhances the antitumor immunity of radiotherapy by activating cGAS".CELL DEATH DISCOVERY 8.1(2022). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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