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Intrinsic and extrinsic pathways of apoptosis induced by multiple antibiotics residues and ocean acidification in hemocytes of scallop Argopecten irradians irradians: An interactionist perspective
Zhang, Tianyu1,2,3; Wang, Xin1,2,3; Zhang, Qianqian1,2; Li, Ke1; Yang, Dinglong1,2; Zhang, Xiaoli1,2; Liu, Hui1,2; Wang, Qing1,2; Dong, Zhijun1,2; Yuan, Xiutang1,2; Zhao, Jianmin1,2,4
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
2024
Volume269Pages:12
KeywordAntibiotics residues Ocean acidification Apoptosis Bay scallop
DOI10.1016/j.ecoenv.2023.115806
Corresponding AuthorZhao, Jianmin(jmzhao@yic.ac.cn)
AbstractThe increasing prevalence of antibiotics in seawater across global coastal areas, coupled with the ocean acidification induced by climate change, present a multifaceted challenge to marine ecosystems, particularly impacting the key physiological processes of marine organisms. Apoptosis is a critical adaptive response essential for maintaining cellular homeostasis and defending against environmental threats. In this study, bay scallops Argopecten irradians irradians were exposed to multiple antibiotics (sulfamethoxazole, tetracycline, oxytetracycline, norfloxacin, and erythromycin, each at a concentration of 1 mu g/L) combined with/without acidic seawater (pH 7.6) for 35 days. The single and interactive effects of the two stressors on apoptosis and the underlying mechanisms in hemocytes of A. irradians irradians were determined through flow cytometry analysis, comet assay, oxidative stress biomarkers analysis, and transcriptome analysis. Results showed that apoptosis could be triggered by either AM exposure or OA exposure, but through different pathways. Exposure to AM leads to mitochondrial dysfunction and oxidative damage, which in turn triggers apoptosis via a series of cellular events in both intrinsic and extrinsic pathways. Conversely, while OA exposure similarly induced apoptosis, its effects are comparatively subdued and are predominantly mediated through the intrinsic pathway. Additionally, the synergistic effects of AM and OA exposure induced pronounced mitochondrial dysfunction and oxidative damages in the hemocytes of A. irradians irradians. Despite the evident cellular distress and the potential initiation of apoptotic pathways, the actual execution of apoptosis appears to be restrained, which might be attributed to an energy deficit within the hemocytes. Our findings underscore the constrained tolerance capacity of A. irradians irradians when faced with multiple environmental stressors, and shed light on the ecotoxicity of antibiotic pollution in the ocean under prospective climate change scenarios.
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences ; National Science & Technology Fundamental Resources Investigation Program of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences
Indexed BySCI
Language英语
WOS KeywordSEAWATER ACIDIFICATION ; OXIDATIVE STRESS ; PACIFIC OYSTER ; DNA-DAMAGE ; CELL-DEATH ; MITOCHONDRIA ; DICLOFENAC ; PHARMACEUTICALS ; BIOACCUMULATION ; RECOGNITION
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS IDWOS:001141450100001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/34333
Collection海岸带生物学与生物资源利用重点实验室
支撑部门_中国科学院牟平海岸带环境综合试验站
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorZhao, Jianmin
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resources Utilizat, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Muping Coastal Environm Res Stn, Yantai Inst Coastal Zone Res, Yantai 264117, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc & Ecol Remediat, Yantai 264117, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Tianyu,Wang, Xin,Zhang, Qianqian,et al. Intrinsic and extrinsic pathways of apoptosis induced by multiple antibiotics residues and ocean acidification in hemocytes of scallop Argopecten irradians irradians: An interactionist perspective[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2024,269:12.
APA Zhang, Tianyu.,Wang, Xin.,Zhang, Qianqian.,Li, Ke.,Yang, Dinglong.,...&Zhao, Jianmin.(2024).Intrinsic and extrinsic pathways of apoptosis induced by multiple antibiotics residues and ocean acidification in hemocytes of scallop Argopecten irradians irradians: An interactionist perspective.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,269,12.
MLA Zhang, Tianyu,et al."Intrinsic and extrinsic pathways of apoptosis induced by multiple antibiotics residues and ocean acidification in hemocytes of scallop Argopecten irradians irradians: An interactionist perspective".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 269(2024):12.
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