Preparation of Novel Chitosan Oligosaccharide Quaternary Ammonium Derivatives Bearing Quinoline with Antioxidative and Antibacterial Activities

doi:10.1002/star.202300001

	Preparation of Novel Chitosan Oligosaccharide Quaternary Ammonium Derivatives Bearing Quinoline with Antioxidative and Antibacterial Activities
	Wang, Linqing 1,2; Zhang, Jingjing 1,3; Liu, Xiguang 2; Tan, Wenqiang1 ; Li, Qing1 ; Guo, Zhanyong1,3
发表期刊	STARCH-STARKE
ISSN	0038-9056
	2023-06-25
页码	10
关键词	biological activities chitosan oligosaccharide derivatives quinoline
DOI	10.1002/star.202300001
通讯作者	Zhang, Jingjing(jingjingzhang@yic.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	In this study, five new chitosan oligosaccharide quaternary ammonium derivatives bearing quinoline are synthesized by reaction between 6-O-chloroacetyl-2-N, N, N-trimethyl quaternary ammonium salt chitosan oligosaccharide (CTCOS, compound 1) and quinoline derivatives. The derivatives are characterized by analytical techniques including Fourier Transform Infrared (FTIR), H-1 Nuclear Magnetic Resonance (H-1 NMR) spectroscopy, and elemental analysis. The obtained results confirm that quinoline groups are successfully introduced into the CTCOS molecule. Meanwhile, the antioxidant activities of the prepared chitosan oligosaccharide derivatives are evaluated in vitro. The experimental results show that the derivatives have excellent free radical scavenging ability. The free radical scavenging abilities are all over 75% at the concentration of 1.6 mg mL(-1). Moreover, antibacterial tests show that derivative 2e has the best antibacterial activities. Its minimum inhibitory concentration (MIC) value and minimum bactericidal concentration (MBC) value against Staphylococcus aureus and Escherichia coli are 0.0625 and 0.03125 mg mL(-1), respectively. In addition, the cytotoxicity of chitosan oligosaccharide and its derivatives is examined by MTT colorimetric assay in RAW 264.7 macrophages, observing that all derivatives are non-cytotoxic. Consequently, the findings indicate that the enhanced antioxidant activity, antibacterial activity, and biocompatibility of these chitosan oligosaccharide derivatives can enlarge the scope of the application of chitosan oligosaccharides, particularly as antioxidant and antibacterial agents in food packaging, pharmaceutical, cosmetics industries, and other fields.
资助机构	Key Deployment Project of Center for Ocean Mega-Science of CAS ; Natural Science Foundation of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Chinese Academy of Sciences
收录类别	SCI
语种	英语
关键词[WOS]	ANTIFUNGAL ; SOLANI
研究领域[WOS]	Food Science & Technology
WOS记录号	WOS:001013586600001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/33340
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Zhang, Jingjing; Guo, Zhanyong
作者单位	1.Yantai Inst Coastal Zone Res, Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Linqing,Zhang, Jingjing,Liu, Xiguang,et al. Preparation of Novel Chitosan Oligosaccharide Quaternary Ammonium Derivatives Bearing Quinoline with Antioxidative and Antibacterial Activities[J]. STARCH-STARKE,2023:10.
APA	Wang, Linqing,Zhang, Jingjing,Liu, Xiguang,Tan, Wenqiang,Li, Qing,&Guo, Zhanyong.(2023).Preparation of Novel Chitosan Oligosaccharide Quaternary Ammonium Derivatives Bearing Quinoline with Antioxidative and Antibacterial Activities.STARCH-STARKE,10.
MLA	Wang, Linqing,et al."Preparation of Novel Chitosan Oligosaccharide Quaternary Ammonium Derivatives Bearing Quinoline with Antioxidative and Antibacterial Activities".STARCH-STARKE (2023):10.