Phenolic Acid Functional Quaternized Chitooligosaccharide Derivatives: Preparation, Characterization, Antioxidant, Antibacterial, and Antifungal Activity

doi:10.3390/md21100535

	Phenolic Acid Functional Quaternized Chitooligosaccharide Derivatives: Preparation, Characterization, Antioxidant, Antibacterial, and Antifungal Activity
	Sun, Yan 1,2,3; Cui, Jingmin 1,2; Tian, Liguang 4; Mi, Yingqi 1,2,3; Guo, Zhanyong1,2
发表期刊	MARINE DRUGS
	2023-10-01
卷号	21 期号:10 页码:22
关键词	chitooligosaccharide chitooligosaccharide quaternary ammonium salt derivatives phenolic acid antioxidant activity antibacterial activity antifungal activity
DOI	10.3390/md21100535
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	As a promising biological material, chitooligosaccharide (COS) has attracted increasing attention because of its unique biological activities. In this study, fourteen novel phenolic acid functional COS derivatives were successfully prepared using two facile methods. The structures of derivatives were characterized by FT-IR and 1H NMR spectra. The in vitro antioxidant activity experiment results demonstrated that the derivatives presented stronger 1,1-Diphenyl-2-picryl-hydrazyl (DPPH), superoxide, hydroxyl radical scavenging activity and reducing power, especially the N,N,N-trimethylated chitooligosaccharide gallic acid salt (GLTMC), gallic acid esterified N,N,N-trimethylated chitooligosaccharide (GL-TMC) and caffeic acid N,N,N-trimethylated chitooligosaccharide (CFTMC) derivatives. Furthermore, the antifungal assay was carried out and the results indicated that the salicylic acid esterified N,N,N-trimethylated chitooligosaccharide (SY-TMC) had much better inhibitory activity against Botrytis cinerea and Fusarium graminearum. Additionally, the results of the bacteriostasis experiment showed that the caffeic acid esterified N,N,N-trimethylated chitooligosaccharide (CF-TMC) had the potential ability to inhibit Escherichia coli and Staphylococcus aureus bacteria. Altogether, this study may provide a neoteric method to produce COS derivatives with significantly increased biological activities, which have potential use in food, medicine, and health care products and other related industries.
资助机构	The authors thank the support of the Yellow River Delta Saline-Alkali Agroecosystem Observation and Research Station.
收录类别	SCI
语种	英语
关键词[WOS]	CARBOXYMETHYL CHITOSAN ; STRESS
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:001093593300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/33280
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shandong Saline Alkali Land Modern Agr Co, Dongying 257300, Peoples R China 4.Yantai Agr Technol Extens Ctr, Yantai 265499, Peoples R China
推荐引用方式 GB/T 7714	Sun, Yan,Cui, Jingmin,Tian, Liguang,et al. Phenolic Acid Functional Quaternized Chitooligosaccharide Derivatives: Preparation, Characterization, Antioxidant, Antibacterial, and Antifungal Activity[J]. MARINE DRUGS,2023,21(10):22.
APA	Sun, Yan,Cui, Jingmin,Tian, Liguang,Mi, Yingqi,&Guo, Zhanyong.(2023).Phenolic Acid Functional Quaternized Chitooligosaccharide Derivatives: Preparation, Characterization, Antioxidant, Antibacterial, and Antifungal Activity.MARINE DRUGS,21(10),22.
MLA	Sun, Yan,et al."Phenolic Acid Functional Quaternized Chitooligosaccharide Derivatives: Preparation, Characterization, Antioxidant, Antibacterial, and Antifungal Activity".MARINE DRUGS 21.10(2023):22.