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pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release
Ma, Bing1,2,3; Li, Qing1,3; Mi, Yingqi1,3; Zhang, Jingjing1,3; Tan, Wenqiang1,3; Guo, Zhanyong1,2,3
KeywordBenzimidazole-chitosan quaternary ammonium salt Nanogels pH-responsive Antioxidant activity Antitumor activity
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
AbstractpH-responsive nanogels have played an increasingly momentous role in tumor treatment. The focus of this study is to design and develop pH-responsive benzimidazole-chitosan quaternary ammonium salt (BIMIXHAC) nanogels for the controlled release of doxorubicin hydrochloride (DOX) while enhancing its hydrophilicity. BIMIXHAC is crosslinked with carboxymethyl chitosan (CMC), hyaluronic acid sodium salt (HA), and sodium alginates (SA) using an ion crosslinking method. The chemical structure of chitosan derivatives was verified by 1H NMR and FT-IR techniques. Compared to hydroxypropyl trimethyl ammonium chloride chitosan (HACC)-based nanogels, BIMIXHAC-based nanogels exhibit better drug encapsulation efficiency and loading capacity (BIMIXHAC-D-HA 91.76 %, and 32.23 %), with pH-responsive release profiles and accelerated release in vitro. The series of nanogels formed by crosslinking with three different polyanionic crosslinkers have different particle size potentials and antioxidant properties. BIMIXHAC-HA, BIMIXHAC-SA and BIMIXHAC-CMC demonstrate favorable antioxidant capability. In addition, cytotoxicity tests showed that BIMIXHAC-based nanogels have high biocompatibility. BIMIXHAC-based nanogels exhibit preferable anticancer effects on MCF-7 and A549 cells. Furthermore, the BIMIXHAC-D-HA nanogel was 2.62 times less toxic than DOX to L929 cells. These results suggest that BIMIXHAC-based nanogels can serve as pH-responsive nanoplatforms for the delivery of anticancer drugs.
Funding OrganizationThe 2023 annual Special Research Assistant Project of Chinese Academy of Sciences ; Shandong Key R D Plan ; Major Scientific and Technological Innovation Project ; Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS IDWOS:001134245300001
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Ma, Bing,Li, Qing,Mi, Yingqi,et al. pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,257:16.
APA Ma, Bing,Li, Qing,Mi, Yingqi,Zhang, Jingjing,Tan, Wenqiang,&Guo, Zhanyong.(2024).pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,257,16.
MLA Ma, Bing,et al."pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 257(2024):16.
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