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Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study
Zhao, Xiaoran1; Wang, Qing2; Li, Xiangfei1; Xu, Hua3; Ren, Chuanbo4; Yang, Yanyan4; Xu, Shuhao1; Wei, Guoxing1; Duan, Yujun1; Tan, Zhitao1; Fang, Yan1
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
2023-05-01
Volume871Pages:13
KeywordProgestin Histology Transcriptome Metabolome Bivalve
DOI10.1016/j.scitotenv.2023.162110
Corresponding AuthorFang, Yan(fly12689@163.com)
AbstractThe potential adverse effects of progestins on aquatic organisms, especially non-target species, are of increasing concern worldwide. However, the effect and mechanism of progestin toxicity on aquatic invertebrates remain largely unexplored. In the present study, clams Mactra veneriformis were exposed to norgestrel (NGT, 0,10, and 1000 ng/L), the dominant progestin detected in the aquatic environment, for 21 days. NGT accumulation, histology, transcriptome, and metabolome were assessed in the digestive gland. The bioconcentration factor (BCF) was 386 and 268 in the 10 ng/L NGT group and 1000 ng/L NGT group, respectively, indicating efficient accumulation of NGT in the clams. Histological analysis showed that NGT led to the swelling of epithelial cells and blurring of the basement membrane in the digestive gland. Differentially-expressed genes and KEGG pathway enrichment analysis using a transcriptomic approach suggested that NGT primarily disturbed the detoxification system, antioxidant defense, carbohydrate and amino acid metabolism, and steroid hormone metabolism, which was consistent with the metabolites analyzed using a metabolomic approach. Furthermore, we speculated that the oxidative stress caused by NGT resulted in histological damage to the digestive gland. This study showed that NGT caused adverse effects in the clams and sheds light on the mechanisms of progestin interference in aquatic invertebrates.
Funding OrganizationNational Natural Science Founda- tion of China ; National Key Research and Devel- opment Program of China ; Ludong University Research Funding
Indexed BySCI
Language英语
WOS KeywordMOSQUITOFISH GAMBUSIA-AFFINIS ; AFFECTS SEX-DIFFERENTIATION ; ACUTE REGULATORY PROTEIN ; MEDROXYPROGESTERONE ACETATE ; MYTILUS-GALLOPROVINCIALIS ; BIOTRANSFORMATION ENZYMES ; STEROID-LEVELS ; LIFE-HISTORY ; EXPOSURE ; EXPRESSION
WOS Research AreaEnvironmental Sciences & Ecology
WOS IDWOS:000990537800001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/32939
Collection海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorFang, Yan
Affiliation1.Ludong Univ, Sch Agr, Yantai 264025, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Peoples R China
3.Yantai Ecol Environm Monitoring Ctr, Yantai 264010, Shandong, Peoples R China
4.Shandong Marine Resource & Environm Res Inst, Shandong Prov Key Lab Restorat Marine Ecol, Yantai 264006, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Xiaoran,Wang, Qing,Li, Xiangfei,et al. Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,871:13.
APA Zhao, Xiaoran.,Wang, Qing.,Li, Xiangfei.,Xu, Hua.,Ren, Chuanbo.,...&Fang, Yan.(2023).Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study.SCIENCE OF THE TOTAL ENVIRONMENT,871,13.
MLA Zhao, Xiaoran,et al."Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study".SCIENCE OF THE TOTAL ENVIRONMENT 871(2023):13.
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