The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro

doi:10.3390/md20110696

	The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro
	Liu, Run-Ze 1,2; Li, Wen-Jun1,2 ; Zhang, Juan-Juan 3; Liu, Zheng-Yi1,2 ; Li, Ya 3; Liu, Chao 3; Qin, Song1,2
发表期刊	MARINE DRUGS
	2022-11-01
卷号	20 期号:11 页码:20
关键词	phycocyanin phycocyanin peptide pulmonary fibrosis inflammatory oxidative stress heme oxygenases-1
DOI	10.3390/md20110696
通讯作者	Liu, Chao(sanmu_363@163.com) ; Qin, Song(sqin@yic.ac.cn)
英文摘要	Phycocyanin is an excellent antioxidant with anti-inflammatory effects on which recent studies are growing; however, its specific target remains unclear. Linear tetrapyrrole compounds such as bilirubin have been shown to lead to the induction of heme oxygenase 1 expression in vivo, thus achieving antioxidant and anti-inflammatory effects. Phycocyanin is bound internally with linear tetrapyrrole phycocyanobilin in a similar structure to bilirubin. We speculate that there is probably a way of inducing the expression of heme oxygenase 1, with which tissue oxidative stress and inflammation can be inhibited, thus inhibiting pulmonary fibrosis caused by oxidative damage and inflammation of lung. By optimizing the enzymatic hydrolysis process, phycocyanobilin-bound phycocyanin peptide were obtained, and its in vitro antioxidant, anti-inflammatory, and anti-pulmonary fibrosis activities were investigated. The results show that the phycocyanobilin peptide was able to alleviate oxidative and inflammatory damage in cells through the Keap1-Nrf2-HO-1 pathway, which in turn relieved pulmonary fibrosis symptoms.
资助机构	National key research and development program of China
收录类别	SCI
语种	英语
关键词[WOS]	HEME OXYGENASE-1 ; RAW264.7 MACROPHAGES ; PROVIDES PROTECTION ; PROTEIN HYDROLYSATE ; C-PHYCOCYANIN ; ACTIVATION ; ANTIOXIDANT ; INFLAMMATION ; CYTOKINES ; OXIDATION
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:000883497200001
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32399
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Liu, Chao; Qin, Song
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 3.Yantai Jiahui Biotech Co Ltd, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Liu, Run-Ze,Li, Wen-Jun,Zhang, Juan-Juan,et al. The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro[J]. MARINE DRUGS,2022,20(11):20.
APA	Liu, Run-Ze.,Li, Wen-Jun.,Zhang, Juan-Juan.,Liu, Zheng-Yi.,Li, Ya.,...&Qin, Song.(2022).The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro.MARINE DRUGS,20(11),20.
MLA	Liu, Run-Ze,et al."The Inhibitory Effect of Phycocyanin Peptide on Pulmonary Fibrosis In Vitro".MARINE DRUGS 20.11(2022):20.