Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities

doi:10.1016/j.carbpol.2022.119943

	Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities
	Zhang, Jingjing 1; Wang, Linqing 2; Tan, Wenqiang1 ; Li, Qing1 ; Dong, Fang1 ; Guo, Zhanyong1,3
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
	2022-11-15
卷号	296 页码:14
关键词	Antioxidant activity Anti-inflammatory activity Chitosan derivatives Rosmarinic acid Structural characterization
DOI	10.1016/j.carbpol.2022.119943
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	In present study, several chitosan derivatives grafted with rosmarinic acid,including chitosan-rosmarinic acid conjugate (CS-RA), chitosan rosmarinic acid salt (CSRA), N,N,N-trimethylated chitosan rosmarinic acid salt (TMCRA), and N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan rosmarinic acid salt (HACRA), were prepared and the effects of different grafting methods on bioactivity of these derivatives were investigated. The structural characterization was identified by FTIR and H-1 NMR spectroscopy. The chitosan derivatives were also evaluated biologically for antioxidant, cytotoxic, and anti-inflammatory activities. Derivatives CSRA, TMCRA, and HACRA prepared through ion exchange method exhibited significant antioxidant ability. All derivatives remarkably inhibited lipopolysaccharide-induced nitric oxide and TNF-alpha production in RAW 264.7 cells without cytotoxicity, especially derivative TMCRA, whose inhibition rate was > 50 % at only 250 mu g/mL. The results suggested that chitosan quaternary ammonium derivatives grafted with rosmarinic acid possessed better anti-oxidant and anti-inflammatory properties than chitosan, which could be used as drug materials against oxidative and inflammation-related pathological processes.
资助机构	National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Chinese Academy of Sciences
收录类别	SCI
语种	英语
关键词[WOS]	IONS ; TOOL
研究领域[WOS]	Chemistry ; Polymer Science
WOS记录号	WOS:000860980900001
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31719
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jingjing,Wang, Linqing,Tan, Wenqiang,et al. Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities[J]. CARBOHYDRATE POLYMERS,2022,296:14.
APA	Zhang, Jingjing,Wang, Linqing,Tan, Wenqiang,Li, Qing,Dong, Fang,&Guo, Zhanyong.(2022).Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities.CARBOHYDRATE POLYMERS,296,14.
MLA	Zhang, Jingjing,et al."Preparation of chitosan-rosmarinic acid derivatives with enhanced antioxidant and anti-inflammatory activities".CARBOHYDRATE POLYMERS 296(2022):14.