Facile synthesis, characterization, antioxidant activity, and antibacterial activity of carboxymethyl inulin salt derivatives | |
Zhang, Jingjing1; Tan, Wenqiang1![]() ![]() | |
发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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ISSN | 0141-8130 |
2022-02-28 | |
卷号 | 199页码:138-149 |
关键词 | Antibacterial activity Antioxidant activity Carboxymethyl inulin salt derivatives |
DOI | 10.1016/j.ijbiomac.2021.12.140 |
通讯作者 | Guo, Zhanyong(zhanyongguo@hotmail.com) |
英文摘要 | A series of novel carboxymethyl inulin derivatives bearing thiosemicarbazide salts, aminoguanidine salts, and aniline salts were prepared via a facile method and employed to evaluate in vitro antioxidant activity and antibacterial activity. Their structures were characterized by Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). The characterization results confirmed the successful synthesis of carboxymethyl inulin salt derivatives. The in vitro antioxidant activity evaluation results presented a significant improved superoxide radical scavenging ability, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability, and reducing ability of carboxymethyl inulin salt derivatives as compared to inulin and carboxymethyl inulin. In particular, the series of carboxymethyl inulin derivatives containing thiosemicarbazide salts and aminoguanidine salts showed remarkable free radical scavenging ability and reducing ability. Moreover, the carboxymethyl inulin derivatives containing thiosemicarbazide salts and aniline salts displayed potential antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria. The cytotoxicity assay was also carried out on L929 cells by CCK-8 method, and all samples showed weak cytotoxicity. Furthermore, hemolysis results showed no hemolytic activity of most prepared inulin derivatives. In summary, the inulin derivatives containing thiosemicarbazide salts exhibited outstanding antioxidant activity, antibacterial activity, and biocompatibility, and the all-inclusive properties highlighted their potential use in food and medical applications. |
资助机构 | National Key Researchand Development Program of China ; Natural Science Foundation of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Chinese Academy of Sciences |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | GRAFTED INULIN |
研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
WOS记录号 | WOS:000781814700004 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/31277 |
专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
通讯作者 | Guo, Zhanyong |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Harbin Inst Technol Weihai, Weihai 264209, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Jingjing,Tan, Wenqiang,Zhao, Pengzhuo,et al. Facile synthesis, characterization, antioxidant activity, and antibacterial activity of carboxymethyl inulin salt derivatives[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2022,199:138-149. |
APA | Zhang, Jingjing,Tan, Wenqiang,Zhao, Pengzhuo,Mi, Yingqi,&Guo, Zhanyong.(2022).Facile synthesis, characterization, antioxidant activity, and antibacterial activity of carboxymethyl inulin salt derivatives.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,199,138-149. |
MLA | Zhang, Jingjing,et al."Facile synthesis, characterization, antioxidant activity, and antibacterial activity of carboxymethyl inulin salt derivatives".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 199(2022):138-149. |
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