The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei | |
Wang, Quanchao1,2,3; Yu, Yang1,3,4; Zhang, Qian1,4,5; Luo, Zheng1,4,5; Zhang, Xiaojun1,3,4; Xiang, Jianhai1,4; Li, Fuhua1,3,4,6 | |
发表期刊 | MARINE BIOTECHNOLOGY |
ISSN | 1436-2228 |
2020-08-01 | |
卷号 | 22期号:4页码:564-571 |
关键词 | Penaeid shrimp Growth traits GWAS Candidate gene MMD2 |
DOI | 10.1007/s10126-020-09977-0 |
通讯作者 | Li, Fuhua(fhli@qdio.ac.cn) |
英文摘要 | The Pacific white shrimpLitopenaeus vannameiis one of the major economic aquaculture species. The growth trait is considered as the most important trait inL. vannameiaquaculture. Identification of the genetic components underlying growth-related traits inL. vannameicould be useful for the selective breeding of growth trait. Our previous work identified several growth-related SNPs by genome-wide association study (GWAS). Based on the assembled genome, we identified a new candidate gene (LvMMD2) beside the associated marker. This gene encodes the progestin and AdipoQ receptor 10 (PAQR10) protein. We further investigate the polymorphisms ofLvMMD2and their association with body weight ofL. vannamei. By resequencing the coding region ofLvMMD2, a total of 8 SNPs were identified, including 6 synonymous mutations and 2 nonsynonymous mutations. Association analyses based on a population of 322 individuals revealed that several SNPs located in the coding region ofLvMMD2were significantly associated with the body weight, especially the nonsynonymous mutation named as MMD_5 contributed the most association to the trait and it could explain 10.5% of phenotypic variance. In addition, several genes involved in growth and development have been identified asLvMMD2-interacting genes. These findings strongly suggested thatLvMMD2might be an important gene regulating the shrimp growth. More importantly, the MMD_5 could be a promising candidate locus for marker-assisted selection (MAS) of the body weight inL. vannamei. |
资助机构 | National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Agricultural Variety Improvement Project of Shandong Province ; China Agriculture Research System-48 |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | GENOME-WIDE ASSOCIATION ; PACIFIC WHITE SHRIMP ; LINKAGE DISEQUILIBRIUM ; IDENTIFICATION ; TOLERANCE ; PERFORMANCE ; GENES ; LOCI |
研究领域[WOS] | Biotechnology & Applied Microbiology ; Marine & Freshwater Biology |
WOS记录号 | WOS:000542504500001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/28719 |
专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
通讯作者 | Li, Fuhua |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Quanchao,Yu, Yang,Zhang, Qian,et al. The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei[J]. MARINE BIOTECHNOLOGY,2020,22(4):564-571. |
APA | Wang, Quanchao.,Yu, Yang.,Zhang, Qian.,Luo, Zheng.,Zhang, Xiaojun.,...&Li, Fuhua.(2020).The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei.MARINE BIOTECHNOLOGY,22(4),564-571. |
MLA | Wang, Quanchao,et al."The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei".MARINE BIOTECHNOLOGY 22.4(2020):564-571. |
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