The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei
Wang, Quanchao1,2,3; Yu, Yang1,3,4; Zhang, Qian1,4,5; Luo, Zheng1,4,5; Zhang, Xiaojun1,3,4; Xiang, Jianhai1,4; Li, Fuhua1,3,4,6
发表期刊MARINE BIOTECHNOLOGY
ISSN1436-2228
2020-08-01
卷号22期号:4页码:564-571
关键词Penaeid shrimp Growth traits GWAS Candidate gene MMD2
DOI10.1007/s10126-020-09977-0
通讯作者Li, Fuhua(fhli@qdio.ac.cn)
英文摘要The Pacific white shrimpLitopenaeus vannameiis one of the major economic aquaculture species. The growth trait is considered as the most important trait inL. vannameiaquaculture. Identification of the genetic components underlying growth-related traits inL. vannameicould be useful for the selective breeding of growth trait. Our previous work identified several growth-related SNPs by genome-wide association study (GWAS). Based on the assembled genome, we identified a new candidate gene (LvMMD2) beside the associated marker. This gene encodes the progestin and AdipoQ receptor 10 (PAQR10) protein. We further investigate the polymorphisms ofLvMMD2and their association with body weight ofL. vannamei. By resequencing the coding region ofLvMMD2, a total of 8 SNPs were identified, including 6 synonymous mutations and 2 nonsynonymous mutations. Association analyses based on a population of 322 individuals revealed that several SNPs located in the coding region ofLvMMD2were significantly associated with the body weight, especially the nonsynonymous mutation named as MMD_5 contributed the most association to the trait and it could explain 10.5% of phenotypic variance. In addition, several genes involved in growth and development have been identified asLvMMD2-interacting genes. These findings strongly suggested thatLvMMD2might be an important gene regulating the shrimp growth. More importantly, the MMD_5 could be a promising candidate locus for marker-assisted selection (MAS) of the body weight inL. vannamei.
资助机构National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Agricultural Variety Improvement Project of Shandong Province ; China Agriculture Research System-48
收录类别SCI
语种英语
关键词[WOS]GENOME-WIDE ASSOCIATION ; PACIFIC WHITE SHRIMP ; LINKAGE DISEQUILIBRIUM ; IDENTIFICATION ; TOLERANCE ; PERFORMANCE ; GENES ; LOCI
研究领域[WOS]Biotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS记录号WOS:000542504500001
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/28719
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Li, Fuhua
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
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Wang, Quanchao,Yu, Yang,Zhang, Qian,et al. The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei[J]. MARINE BIOTECHNOLOGY,2020,22(4):564-571.
APA Wang, Quanchao.,Yu, Yang.,Zhang, Qian.,Luo, Zheng.,Zhang, Xiaojun.,...&Li, Fuhua.(2020).The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei.MARINE BIOTECHNOLOGY,22(4),564-571.
MLA Wang, Quanchao,et al."The Polymorphism ofLvMMD2and Its Association with Growth Traits inLitopenaeus vannamei".MARINE BIOTECHNOLOGY 22.4(2020):564-571.
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