| Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection | |
Wang, Mingchao1,4; Chen, Jian2; Li, Wenjun1,3 ; Zang, Fan1,4; Liu, Xuexia2; Qin, Song1,3
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| 发表期刊 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
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| ISSN | 0928-4931 |
| 2020-09-01 | |
| 卷号 | 114页码:10 |
| 关键词 | Double network hydrogel Paclitaxel Nanoparticle Breast cancer Local treatment |
| DOI | 10.1016/j.msec.2020.111046 |
| 通讯作者 | Li, Wenjun(wjli@yic.ac.cn) ; Qin, Song(sqin@yic.ac.cn) |
| 英文摘要 | Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of tumors such as breast cancer. We hypothesize that paclitaxel-nanoparticles-loaded double network (PTX-NPs-DN) hydrogel can deliver PTX locally and sustainably in the tumor resection cavity. In this study, hydrogels loaded with PTX-NPs were prepared via self-assembly of collagen and self-crosslinking of polyvinyl alcohol (PVA). The hydrogel with a porous structure has a compressive modulus of 33 kPa at a strain of 40%. In this system, PTX release presented a linear release kinetic over 10 days in vitro and higher accumulating concentrations of PTX in local adipose tissue than in plasma. The biocompatibility studies show that PTX-NPs-DN hydrogel did not induce cytotoxicity in different cell lines (MCF-7, L929s) and hemolysis in vitro nor inflammatory response in vivo. In vivo anti-tumor efficacy study, compared with all other groups, significantly decreased tumor weight and improved capacity to slow down tumor recurrences were observed in the group treated with PTX-NPs-DN hydrogel. In conclusion, this proof-of-concept study demonstrated the feasibility, tolerability and efficiency of PTX-NPs-DN hydrogel for the local treatment of breast cancer. |
| 资助机构 | Major Science and Technology Innovation Project of Shandong Province (China) ; Marine Economy Innovation Development Demonstration Project ; National Key Research and Development Program of China |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | DRUG-DELIVERY SYSTEMS ; RELEASE ; PLGA ; BIOMATERIALS ; THERAPY |
| 研究领域[WOS] | Materials Science |
| WOS记录号 | WOS:000579654700026 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/28456 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Li, Wenjun; Qin, Song |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Qingdao Univ, Dept Oncol, Affiliated Yantai Yuhuangding Hosp, Yantai, Shandong, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 4.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Mingchao,Chen, Jian,Li, Wenjun,et al. Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2020,114:10. |
| APA | Wang, Mingchao,Chen, Jian,Li, Wenjun,Zang, Fan,Liu, Xuexia,&Qin, Song.(2020).Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,114,10. |
| MLA | Wang, Mingchao,et al."Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 114(2020):10. |
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| Paclitaxel-nanoparti（9474KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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