| A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells | |
Pu, Yang1,3; Wei, Mengjiao1; Witkowski, Andrzej4; Krzywda, Marta4; Wang, Yinchu2 ; Li, Wenjun2
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| Source Publication | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| ISSN | 0006-291X |
| 2020-12-10 | |
| Volume | 533Issue:3Pages:573-579 |
| Keyword | Biofunctional biosilica C-phycocyanin Phycocyanobilin Enhanced photodynamic effect Nanocarriers |
| DOI | 10.1016/j.bbrc.2020.09.049 |
| Corresponding Author | Pu, Yang(ypu@ldu.edu.cn) ; Li, Wenjun(wjli@yic.ac.cn) |
| Abstract | Intricate mesoporous biosilica has many biomedical applications as a nanocarrier. However, its potential use in photodynamic therapy (PDT) has received little attention. This work reports the first fabrication of bio-engineered materials by covalently conjugating C-phycocyanin (C-PC), a natural photosensitizer, to biosilica for the PDT of tumor-associated macrophages. The resulting hybrid material showed outstanding photodynamic activity under 620 nm laser irradiation. Furthermore, it enhanced the relatively weak photodynamic effect of C-PC. This study also explored methods of biofunctionalizing biosilica for cancer phototherapy, a new pharmacological application of non-toxic C-PC. (C) 2020 Elsevier Inc. All rights reserved. |
| Funding Organization | National Natural Science Foundation of China ; Key Research and Development Program of Yantai ; TEAM-NET programme of the Foundation for Polish Science ; European Union under the European Regional Development Fund |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | APOPTOSIS ; DIATOMS ; PHYCOBILIPROTEINS ; PHYCOBILISOMES ; ANTIOXIDANT ; CYCLE ; DRUG |
| WOS Research Area | Biochemistry & Molecular Biology ; Biophysics |
| WOS ID | WOS:000588268300046 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/28321 |
| Collection | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| Corresponding Author | Pu, Yang; Li, Wenjun |
| Affiliation | 1.Ludong Univ, Sch Agr, Yantai 264025, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Ludong Univ, Bionanotechnol Res Inst, Yantai 264025, Peoples R China 4.Univ Szczecin, Inst Marine & Environm Sci, Szczecin, Poland |
| Recommended Citation GB/T 7714 | Pu, Yang,Wei, Mengjiao,Witkowski, Andrzej,et al. A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020,533(3):573-579. |
| APA | Pu, Yang,Wei, Mengjiao,Witkowski, Andrzej,Krzywda, Marta,Wang, Yinchu,&Li, Wenjun.(2020).A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533(3),573-579. |
| MLA | Pu, Yang,et al."A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533.3(2020):573-579. |
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| File Name/Size | DocType | Version | Access | License | ||
| A hybrid biomaterial（1635KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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