YIC-IR  > 海岸带生物学与生物资源利用重点实验室
A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells
Pu, Yang1,3; Wei, Mengjiao1; Witkowski, Andrzej4; Krzywda, Marta4; Wang, Yinchu2; Li, Wenjun2
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN0006-291X
2020-12-10
Volume533Issue:3Pages:573-579
KeywordBiofunctional biosilica C-phycocyanin Phycocyanobilin Enhanced photodynamic effect Nanocarriers
DOI10.1016/j.bbrc.2020.09.049
Corresponding AuthorPu, Yang(ypu@ldu.edu.cn) ; Li, Wenjun(wjli@yic.ac.cn)
AbstractIntricate mesoporous biosilica has many biomedical applications as a nanocarrier. However, its potential use in photodynamic therapy (PDT) has received little attention. This work reports the first fabrication of bio-engineered materials by covalently conjugating C-phycocyanin (C-PC), a natural photosensitizer, to biosilica for the PDT of tumor-associated macrophages. The resulting hybrid material showed outstanding photodynamic activity under 620 nm laser irradiation. Furthermore, it enhanced the relatively weak photodynamic effect of C-PC. This study also explored methods of biofunctionalizing biosilica for cancer phototherapy, a new pharmacological application of non-toxic C-PC. (C) 2020 Elsevier Inc. All rights reserved.
Funding OrganizationNational Natural Science Foundation of China ; Key Research and Development Program of Yantai ; TEAM-NET programme of the Foundation for Polish Science ; European Union under the European Regional Development Fund
Indexed BySCI
Language英语
WOS KeywordAPOPTOSIS ; DIATOMS ; PHYCOBILIPROTEINS ; PHYCOBILISOMES ; ANTIOXIDANT ; CYCLE ; DRUG
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000588268300046
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/28321
Collection海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
Corresponding AuthorPu, Yang; Li, Wenjun
Affiliation1.Ludong Univ, Sch Agr, Yantai 264025, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
3.Ludong Univ, Bionanotechnol Res Inst, Yantai 264025, Peoples R China
4.Univ Szczecin, Inst Marine & Environm Sci, Szczecin, Poland
Recommended Citation
GB/T 7714
Pu, Yang,Wei, Mengjiao,Witkowski, Andrzej,et al. A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020,533(3):573-579.
APA Pu, Yang,Wei, Mengjiao,Witkowski, Andrzej,Krzywda, Marta,Wang, Yinchu,&Li, Wenjun.(2020).A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533(3),573-579.
MLA Pu, Yang,et al."A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533.3(2020):573-579.
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