| Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray | |
Liu, Qi1; Li, Wenjun1,2 ; Qin, Song1,2
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| 发表期刊 | BIOMEDICINE & PHARMACOTHERAPY
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| ISSN | 0753-3322 |
| 2020-10-01 | |
| 卷号 | 130页码:7 |
| 关键词 | phycocyanin Radiation Oxidative stress Liver damage Nrf2/ HO-1 signaling pathway DNA damage |
| DOI | 10.1016/j.biopha.2020.110553 |
| 通讯作者 | Li, Wenjun(wjli@yic.ac.cn) ; Qin, Song(sqin@yic.an.cn) |
| 英文摘要 | 1) Background: Phycocyanin (PC) is a type of natural protein in algae with antioxidant and anti-inflammatory properties. However, the protective effect of PC on hepatic damage induced by X-ray remains unknown. 2) Methods: Male C57BL/6 mice were gavaged with 200mg/kg PC for consecutive 7 days before or after radiation. The blood samples and tissues were collected on days 1 and 7 after radiation exposure. 3) Results: Pretreatment or treatment with PC decreased significantly the levels of alanine aminotransferase (ALT), aspartate aminotransferase(AST) in the plasma. Histological evaluation further confirmed the protection of PC against radiation-induced hepatotoxicity. PC-treatment also increased the relative mRNA expression of superoxide dismutase (SOD) and glutathione (GSH-PX), and descended the ROS in the liver. Moreover, the expression of H2AX, an indicator of DNA damage in mice, of the PC-intervention group was much smaller than that of the radiation group. In vivo, PC-treatment markedly up-regulated NF-E2-related factor 2(Nrf2) expression and downstream gene such as hemeoxygenase-1 (HO-1), NQO1. 4) Conclusion: PC could attenuate the radiation-induced oxidative stress damage by activating Nrf2/ HO-1 signaling pathway, and reduce the radiation-induced DNA damage. Therefore, PC is a protective agent against radiation-induced liver damage. |
| 资助机构 | National Key Research and Development Program of China ; Marine Economy Innovation Development Demonstration Project ; KeyResearch and Development Program of Yantai |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | SPIRULINA-PLATENSIS ; RADIATION ; INJURY ; NRF2 ; ANTIOXIDANT ; MICE ; ACTIVATION ; MODEL |
| 研究领域[WOS] | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000582697900058 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/28306 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Li, Wenjun; Qin, Song |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qi,Li, Wenjun,Qin, Song. Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray[J]. BIOMEDICINE & PHARMACOTHERAPY,2020,130:7. |
| APA | Liu, Qi,Li, Wenjun,&Qin, Song.(2020).Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray.BIOMEDICINE & PHARMACOTHERAPY,130,7. |
| MLA | Liu, Qi,et al."Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray".BIOMEDICINE & PHARMACOTHERAPY 130(2020):7. |
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