| Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum | |
Liu, Ya-Ping1,2; Fang, Sheng-Tao1 ; Shi, Zhen-Zhen1; Wang, Bin-Gui3; Li, Xiao-Nian4; Ji, Nai-Yun1
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| 发表期刊 | MARINE DRUGS
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| 2021 | |
| 卷号 | 19期号:1页码:10 |
| 关键词 | Penicillium oxalicum deep sea cold seep phenylhydrazone quinazoline |
| DOI | 10.3390/md19010009 |
| 通讯作者 | Ji, Nai-Yun(nyji@yic.ac.cn) |
| 英文摘要 | Three new phenylhydrazones, penoxahydrazones A-C (compounds 1-3), and two new quinazolines, penoxazolones A (compound 4) and B (compound 5), with unique linkages were isolated from the fungus Penicillium oxalicum obtained from the deep sea cold seep. Their structures and relative configurations were assigned by analysis of 1D/2D NMR and mass spectroscopic data, and the absolute configurations of 1, 4, and 5 were established on the basis of X-ray crystallography or ECD calculations. Compound 1 represents the first natural phenylhydrazone-bearing steroid, while compounds 2 and 3 are rarely occurring phenylhydrazone tautomers. Compounds 4 and 5 are enantiomers that feature quinazoline and cinnamic acid units. Some isolates exhibited inhibition of several marine phytoplankton species and marine-derived bacteria. |
| 资助机构 | National Key R&D Program of China ; Taishan Scholar Project ; Shuangbai Plan of Yantai ; Youth Innovation Promotion Association of CAS ; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| WOS记录号 | WOS:000611035300001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/27475 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Ji, Nai-Yun |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Ctr Ocean Mega Sci, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Ctr Ocean Mega Sci, Inst Oceanol,Key Lab Expt Marine Biol,Lab Marine, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ya-Ping,Fang, Sheng-Tao,Shi, Zhen-Zhen,et al. Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum[J]. MARINE DRUGS,2021,19(1):10. |
| APA | Liu, Ya-Ping,Fang, Sheng-Tao,Shi, Zhen-Zhen,Wang, Bin-Gui,Li, Xiao-Nian,&Ji, Nai-Yun.(2021).Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum.MARINE DRUGS,19(1),10. |
| MLA | Liu, Ya-Ping,et al."Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum".MARINE DRUGS 19.1(2021):10. |
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| Phenylhydrazone and （1228KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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