| Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2 | |
Shi, Zhen-Zhen1; Liu, Xiang-Hong1,2; Li, Xiao-Nian3; Ji, Nai-Yun1
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| 发表期刊 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| ISSN | 0021-8561 |
| 2020-12-30 | |
| 卷号 | 68期号:52页码:15440-15448 |
| 关键词 | Trichoderma brevicompactum trichothecene cuparene antifungal activity antimicroalgal activity |
| DOI | 10.1021/acs.jafc.0c05586 |
| 通讯作者 | Ji, Nai-Yun(nyji@yic.ac.cn) |
| 英文摘要 | Eight new trichothecene derivatives, trichodermarins G-N (1-8), and two new cuparene derivatives, trichocuparins A (9) and B (10), as well as six known trichothecenes (11-16) were isolated from the fungal strain Trichoderma brevicompactum A-DL-9-2 obtained from the inner tissue of the marine red alga Chondria tenuissima. The structures and relative configurations of 1-10 were assigned by NMR and MS data, and the absolute configurations of 1, 2, and 9 were established by X-ray diffraction. Compound 8 features an aminosugar unit bond to the trichothecene framework for the first time, while 9 and 10 represent the first occurrence of cuparene sesquiterpenes in Trichoderma. All the isolates were assayed for growth inhibition of five phytopathogenic fungi (Botrytis cinerea, Cochliobolus miyabeanus, Fusarium oxysporum f. sp. cucumerium, Fusarium oxysporum f. sp. niveum, and Phomopsis asparagi) and four marine phytoplankton species (Amphidinium carterae, Heterocapsa circularisquama, Heterosigma akashiwo, and Prorocentrum donghaiense). Several of them exhibited significant inhibitory activities against the fungi and phytoplankton tested of which trichodermin (12) showed the highest antifungal and antimicroalgal activities with MIC and IC50 values being 4.0 and 0.82 mu g/mL, respectively. |
| 资助机构 | Natural Science Foundation for Distinguished Young Scholars of Shandong Province ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of CAS ; Taishan Scholar Project Special Funding |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | BOTRYTIS-CINEREA ; BIOSYNTHESIS ; DERIVATIVES ; MYCOTOXINS ; INHIBITORS ; IMPACTS ; BLOOMS |
| 研究领域[WOS] | Agriculture ; Chemistry ; Food Science & Technology |
| WOS记录号 | WOS:000605190400009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/26159 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Ji, Nai-Yun |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Megasci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Zhen-Zhen,Liu, Xiang-Hong,Li, Xiao-Nian,et al. Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(52):15440-15448. |
| APA | Shi, Zhen-Zhen,Liu, Xiang-Hong,Li, Xiao-Nian,&Ji, Nai-Yun.(2020).Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(52),15440-15448. |
| MLA | Shi, Zhen-Zhen,et al."Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.52(2020):15440-15448. |
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