Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2
Shi, Zhen-Zhen1; Liu, Xiang-Hong1,2; Li, Xiao-Nian3; Ji, Nai-Yun1
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
2020-12-30
Volume68Issue:52Pages:15440-15448
KeywordTrichoderma brevicompactum trichothecene cuparene antifungal activity antimicroalgal activity
DOI10.1021/acs.jafc.0c05586
Corresponding AuthorJi, Nai-Yun(nyji@yic.ac.cn)
AbstractEight new trichothecene derivatives, trichodermarins G-N (1-8), and two new cuparene derivatives, trichocuparins A (9) and B (10), as well as six known trichothecenes (11-16) were isolated from the fungal strain Trichoderma brevicompactum A-DL-9-2 obtained from the inner tissue of the marine red alga Chondria tenuissima. The structures and relative configurations of 1-10 were assigned by NMR and MS data, and the absolute configurations of 1, 2, and 9 were established by X-ray diffraction. Compound 8 features an aminosugar unit bond to the trichothecene framework for the first time, while 9 and 10 represent the first occurrence of cuparene sesquiterpenes in Trichoderma. All the isolates were assayed for growth inhibition of five phytopathogenic fungi (Botrytis cinerea, Cochliobolus miyabeanus, Fusarium oxysporum f. sp. cucumerium, Fusarium oxysporum f. sp. niveum, and Phomopsis asparagi) and four marine phytoplankton species (Amphidinium carterae, Heterocapsa circularisquama, Heterosigma akashiwo, and Prorocentrum donghaiense). Several of them exhibited significant inhibitory activities against the fungi and phytoplankton tested of which trichodermin (12) showed the highest antifungal and antimicroalgal activities with MIC and IC50 values being 4.0 and 0.82 mu g/mL, respectively.
Indexed BySCI
Language英语
WOS KeywordBOTRYTIS-CINEREA ; BIOSYNTHESIS ; DERIVATIVES ; MYCOTOXINS ; INHIBITORS ; IMPACTS ; BLOOMS
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
Funding ProjectNatural Science Foundation for Distinguished Young Scholars of Shandong Province[JQ201712] ; National Natural Science Foundation of China[42076096] ; Youth Innovation Promotion Association of CAS[Y201734] ; Taishan Scholar Project Special Funding[tsqn201909164]
WOS IDWOS:000605190400009
Funding OrganizationNatural Science Foundation for Distinguished Young Scholars of Shandong Province ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of CAS ; Taishan Scholar Project Special Funding
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/26159
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
Corresponding AuthorJi, Nai-Yun
Affiliation1.Chinese Acad Sci, Ctr Ocean Megasci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Shi, Zhen-Zhen,Liu, Xiang-Hong,Li, Xiao-Nian,et al. Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(52):15440-15448.
APA Shi, Zhen-Zhen,Liu, Xiang-Hong,Li, Xiao-Nian,&Ji, Nai-Yun.(2020).Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(52),15440-15448.
MLA Shi, Zhen-Zhen,et al."Antifungal and Antimicroalgal Trichothecene Sesquiterpenes from the Marine Algicolous Fungus Trichoderma brevicompactum A-DL-9-2".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.52(2020):15440-15448.
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