Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges

doi:10.1177/0883911520981705

	Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges
	Wang, Tong 1; Yang, Lintong 1; Wang, Guangfei 1; Han, Lei 1; Chen, Kaili 1; Liu, Ping 1; Xu, Shumin 1; Li, Dongsheng 2; Xie, Zeping 3; Mo, Xiumei 2; Wang, Lei4 ; Liang, Haiyue 5; Liu, Xuejie 5; Zhang, Shumin 3; Gao, Yonglin 1
发表期刊	JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
ISSN	0883-9115
	2021
卷号	36 期号:1 页码:44-58
关键词	tilapia skin collagen collagen sponge biocompatibility wound healing hemostatic properties
DOI	10.1177/0883911520981705
通讯作者	Zhang, Shumin(shumin_zhang@outlook.com) ; Gao, Yonglin(gylbill@163.com)
英文摘要	Dialyzed tilapia skin collagen sponge (DTSCS) and self-assembled tilapia skin collagen sponge (STSCS) were prepared by freeze-drying. The raw components used in the fabrication of DTSCS and STSCS were separated and purified from tilapia fish skin. It is anticipated that these collagen sponges could be developed into medical dressings for hemostasis and wound healing. The aim of the present research was to explore the possibility of DTSCS and STSCS as medical dressings and compare their differences by scanning electron microscopy (SEM), water absorption measurement, differential scanning calorimetry (DSC), measurement of porosity, cytotoxicity, hemolysis, in vivo biocompatibility, and evaluation of hemostatic performance and wound healing. The results indicate that DTSCS and STSCS are suitable materials for use in medical applications with a loose and porous structure, high water absorption, high porosity, and high thermal stability. The materials also displayed good biocompatibility, including excellent blood compatibility, a lack of cytotoxicity, with no apparent rejection following implantation. STSCS exhibited rapid hemostasis and promoted healing, with slightly greater efficacy than DTSCS. The hemostatic properties and promotion of healing in DTSCS was similar to that of commercial bovine collagen sponge. Therefore, DTSCS and STSCS both represented excellent potential candidate materials for use as hemostatic agents and wound dressings.
收录类别	SCI
语种	英语
研究领域[WOS]	Biotechnology & Applied Microbiology ; Materials Science ; Polymer Science
WOS记录号	WOS:000605949700004
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/26155
专题	中国科学院烟台海岸带研究所知识产出中国科学院烟台海岸带研究所
通讯作者	Zhang, Shumin; Gao, Yonglin
作者单位	1.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 2.Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 5.Yantai Testing Ctr Food & Drug, Yantai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Tong,Yang, Lintong,Wang, Guangfei,et al. Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2021,36(1):44-58.
APA	Wang, Tong.,Yang, Lintong.,Wang, Guangfei.,Han, Lei.,Chen, Kaili.,...&Gao, Yonglin.(2021).Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,36(1),44-58.
MLA	Wang, Tong,et al."Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 36.1(2021):44-58.

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