Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives
Chen, Yuan; Liu, Xiguang; Sun, Xueqi; Zhang, Jingjing; Mi, Yingqi; Li, Qing; Guo, Zhanyong
Source PublicationPOLYMERS
2020-01
Volume12Issue:1Pages:112
KeywordCHITOSAN DERIVATIVES CLICK REACTION POLYSACCHARIDE
MOST Discipline CataloguePolymer Science
DOI10.3390/polym12010112
Contribution Rank[Chen, Yuan; Liu, Xiguang] Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China; [Chen, Yuan; Sun, Xueqi; Zhang, Jingjing; Mi, Yingqi; Li, Qing; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Chen, Yuan; Sun, Xueqi; Zhang, Jingjing; Mi, Yingqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Department海岸带生物资源高效利用研究与发展中心
AbstractIn this study, starch was chemically modified to improve its antioxidant activity. Five novel cationic 1,2,3-triazole functionalized starch derivatives were synthesized by using "click" reaction and N-alkylation. A convenient method for pre-azidation of starch was developed. The structures of the derivatives were analyzed using FTIR and H-1 NMR. The radicals scavenging abilities of the derivatives against hydroxyl radicals, DPPH radicals, and superoxide radicals were tested in vitro in order to evaluate their antioxidant activity. Results revealed that all the cationic starch derivatives (2a-2e), as well as the precursor starch derivatives (1a-1e), had significantly improved antioxidant activity compared to native starch. In particular, the scavenging ability of the derivatives against superoxide radicals was extremely strong. The improved antioxidant activity benefited from the enhanced solubility and the added positive charges. The biocompatibility of the cationic derivatives was confirmed by the low hemolytic rate (<2%). The obtained derivatives in this study have great potential as antioxidant materials that can be applied in the fields of food and biomedicine.
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordCHITOSAN DERIVATIVES ; CLICK REACTION ; POLYSACCHARIDE
WOS IDWOS:000519848300112
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; National Key R&D Program of China [2019YFD0900705] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; Science and Technology Service Network Initiative of Chinese academy of sciences [KFJ-STS-ZDTP-023] ; Public Science and Technology Research Funds Projects of Ocean [2015418022-3] ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011]
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Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/25100
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Affiliation1.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China;
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Chen, Yuan,Liu, Xiguang,Sun, Xueqi,et al. Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives[J]. POLYMERS,2020,12(1):112.
APA Chen, Yuan.,Liu, Xiguang.,Sun, Xueqi.,Zhang, Jingjing.,Mi, Yingqi.,...&Guo, Zhanyong.(2020).Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives.POLYMERS,12(1),112.
MLA Chen, Yuan,et al."Synthesis and Antioxidant Activity of Cationic 1,2,3-Triazole Functionalized Starch Derivatives".POLYMERS 12.1(2020):112.
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