| The effects of benzo[a]pyrene on the composition of gut microbiota and the gut health of the juvenile sea cucumber Apostichopus japonicus Selenka | |
Zhao, Y; Liu, H ; Wang, Q; Li, BJ; Zhang, HX; Pi, YR
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| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
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| ISSN | 1050-4648 |
| 2019-10 | |
| 卷号 | 93页码:369-379 |
| 关键词 | Benzo[a]pyrene Sea cucumber Gut microbiota 16S rRNA Gene sequencing |
| 研究领域 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| DOI | 10.1016/j.fsi.2019.07.073 |
| 产权排序 | [Zhao, Ye; Li, Bingjun; Pi, Yongrui] Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China; [Liu, Hui; Wang, Qing; Zhang, Hongxia] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai, Peoples R China |
| 通讯作者 | Zhao, Ye(zyzy19872006@ytu.edu.cn) ; Wang, Qing(qingwang@yic.ac.cn) |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | The gut microbiota is essential for health and physiological functions in the host organism. However, the toxicological evaluation of environmental pollutants on the gut microbiota is still insufficient. In the present study, the juvenile sea cucumber Apostichopus japonicus was exposed for 14 days to Benzo[a]pyrene (BaP), which is a model polycyclic aromatic hydrocarbon (PAH), at four different concentrations (0, 0.5, 5, and 25 mu g/L). We analyzed the intestinal microbial community of A. japonicas using 16S rRNA gene amplicon sequencing. Our results demonstrate that BaP exposure caused alterations to the microbiome community composition in sea cucumbers. At the phylum level, Planctomycetes were significantly more abundant in BaP exposure groups at 14 d compared with the control group, and the abundance of Proteobacteria and Bacteroidetes increased while the abundance of Firmicutes decreased following BaP exposure. At the genus level, multiple beneficial and autochthonous genera declined in the BaP treatment groups compared to the control, including Lactococcus, Bacillus, Lactobacillus, Enterococcus, Leuconostoc and Weissella; however, a bloom of alkane-degrading bacteria was found in BaP-exposed guts and included Lutibacter, Pseudoalteromonas, Polaribacter, Rhodopirellula and Blastopirellula. Furthermore, histological morphology, enzymatic activity and gene expression analysis revealed that BaP exposure also negatively impacted gut structure and function and presented as inflammation or atrophy, oxidative stress and immune suppression in sea cucumber intestines. Collectively, these findings provide insights into the toxic effects of BaP exposure on A. japonicas associated with intestinal microbiota and health. |
| 文章类型 | Article |
| 资助机构 | Shandong Provincial Natural Science FoundationNatural Science Foundation of Shandong Province [ZR2017BD026] ; Yantai University Doctoral Start-up Foundation [HX15B14] ; Demonstration Project on Innovative Development of Marine Economy Foundation [YHCX-SW-P-201701] ; Science and Technology Service Network Initiative (STS) Project [KFJ-STS-ZDTP-023] ; Instrument Developing Project of the Chinese Academy of Sciences [YJKYYQ20170071] ; Youth Innovation Promotion Association, CAS [2016196] ; Two-Hundred Talents Plan of Yantai [Y839081021] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | AROMATIC-HYDROCARBONS PAHS ; INTESTINAL MICROBIOME ; EMBRYONIC EXPOSURE ; ENERGY-METABOLISM ; ORAL-EXPOSURE ; DNA-DAMAGE ; RESPONSES ; GROWTH ; DYSBIOSIS ; SEDIMENTS |
| 研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS记录号 | WOS:000488998300043 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24846 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 作者单位 | 1.Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Y,Liu, H,Wang, Q,et al. The effects of benzo[a]pyrene on the composition of gut microbiota and the gut health of the juvenile sea cucumber Apostichopus japonicus Selenka[J]. FISH & SHELLFISH IMMUNOLOGY,2019,93:369-379. |
| APA | Zhao, Y,Liu, H,Wang, Q,Li, BJ,Zhang, HX,&Pi, YR.(2019).The effects of benzo[a]pyrene on the composition of gut microbiota and the gut health of the juvenile sea cucumber Apostichopus japonicus Selenka.FISH & SHELLFISH IMMUNOLOGY,93,369-379. |
| MLA | Zhao, Y,et al."The effects of benzo[a]pyrene on the composition of gut microbiota and the gut health of the juvenile sea cucumber Apostichopus japonicus Selenka".FISH & SHELLFISH IMMUNOLOGY 93(2019):369-379. |
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