Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9 | |
Liu, YJ1; Zhang, JL1,3; Li, C1; Mu, XG1; Liu, XL1; Wang, L1; Zhao, YC1; Zhang, P4; Li, XD1,2; Zhang, XX1 | |
发表期刊 | MOLECULES |
ISSN | 1420-3049 |
2019-12 | |
卷号 | 24期号:24页码:4596 |
关键词 | Aspergillus sydowii seawater-derived fungus secondary metabolites antimicrobial activity |
研究领域 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
DOI | 10.3390/molecules24244596 |
产权排序 | [Liu, Yu-Jing ; Zhang, Jian-Long; Li, Chen; Mu, Xue-Gen; Liu, Xiao-Li; Wang, Lei; Zhao, Yan-Cui; Li, Xiao-Dong; Zhang, Xing-Xiao] Ludong Univ, Key Lab Marine Biotechnol Univ Shandong, Sch Life Sci, Yantai 264025, Peoples R China; [Li, Xiao-Dong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhang, Jian-Long] Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China; [Zhang, Peng] Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China |
作者部门 | 中科院烟台海岸带研究所知识产出 |
英文摘要 | Marine-derived fungi are considered to be valuable producers of bioactive secondary metabolites used as lead compounds with medicinal importance. In this study, chemical investigation of the seawater-derived fungus Aspergillus sydowii SW9 led to the isolation and identification of one new quinazolinone alkaloid, 2-(4-hydroxybenzyl)-4-(3-acetyl)quinazolin-one (1), one new aromatic bisabolene-type sesquiterpenoid, (2) and one new chorismic acid analogue (3), as well as two known alkaloids (compounds 4 and 5). Their structures were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of 2 and 3 were assigned by the analysis of ECD spectra aided by quantum chemical computations. Compounds 1, 2, and 4 exhibited selective inhibitory activities against the human pathogenic bacteria Escherichia coli, Staphylococcus aureus, S. epidermidis, and Streptococcus pneumoniae, with MIC values ranging from 2.0 to 16 mu g/mL. |
文章类型 | Article |
资助机构 | National Key Research and Development Program of China [2016YFD0501010] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31700043, 41506190, 81600672] ; Key Research and Development Program of Shandong Province [2019GSF107091] ; Major Agricultural Applied Technological Innovation Projects of Shandong Province ; Key Research and Development Plan of Yantai [2018XSCC045] ; Innovation Team Project for Modern Agricultural Industrious Technology System of Shandong Province [SDAIT-11-10] |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | XANTHONE DERIVATIVES ; ENDOPHYTIC FUNGUS ; SYDONIC ACID ; ANALOGS |
研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
WOS记录号 | WOS:000507299600174 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/24797 |
专题 | 中国科学院烟台海岸带研究所知识产出 |
通讯作者 | Li, XD; Zhang, XX |
作者单位 | 1.Ludong Univ, Key Lab Marine Biotechnol Univ Shandong, Sch Life Sci, Yantai 264025, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 3.Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China; 4.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, YJ,Zhang, JL,Li, C,et al. Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9[J]. MOLECULES,2019,24(24):4596. |
APA | Liu, YJ.,Zhang, JL.,Li, C.,Mu, XG.,Liu, XL.,...&Zhang, XX.(2019).Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9.MOLECULES,24(24),4596. |
MLA | Liu, YJ,et al."Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9".MOLECULES 24.24(2019):4596. |
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