| Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels | |
Wang, Mingchao; Li, Jie ; Li, Wenjun; Du, Zhenning; Qin, Song
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| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| 2018-10-15 | |
| 卷号 | 118期号:A页码:41-48 |
| 关键词 | Collagen Poly (vinyl alcohol) Double-network Hydrogel Self-crosslink |
| 研究领域 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| DOI | 10.1016/j.ijbiomac.2018.05.200 |
| 产权排序 | [Wang, Mingchao; Du, Zhenning] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China; [Li, Jie; Li, Wenjun; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 作者部门 | 海岸带生物学与生物资源保护实验室 |
| 英文摘要 | Hydrogels prepared by conventional methods show poor performance in many aspects. Many double network (DN) hydrogels prepared by crosslinking agents have disadvantages such as toxicity. In this work, we prepared novel DN hydrogels with fish-originated collagen (Col) and poly (vinyl alcohol) (PVA), in which self-assembly of collagen and self-crosslinking of PVA were achieved. Infrared spectra indicated the existence of double network with chemical interactions between Col and PVA. X-ray diffraction (XRD) patterns showed that characteristic peak of freeze-thaw PVA in DN hydrogel was retained. Scanning electron microscope (SEM) images before and after degradation and swelling property tests indicated that the morphology of the hydrogel was a compact meshwork, which is consistent with the high water-retention rate. The degradation rate of the DN hydrogels was controlled by the ratio of Col and PVA. Compared with a pure collagen hydrogels, the stress of DN hydrogels was greatly enhanced from 6 to 33 kPa at a strain of 40%. This study indicates that DN hydrogels prepared by Col and PVA are an ideal biomaterial for tissue engineering. (C) 2018 Published by Elsevier B.V. |
| 文章类型 | Article |
| 资助机构 | Yantai Innovative Marine Medical Materials Industry Incubation Aggregation Innovation and Demonstration Project [YHCX-SW-Y-201701] ; National Key Research and Development Program China [2016YFF0202304] ; [KFZD-SW-218] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | MECHANICAL-PROPERTIES ; COLLAGEN HYDROGELS ; BONE REGENERATION ; ALCOHOL HYDROGEL ; HYBRID HYDROGELS ; SKIN COLLAGEN ; FISH COLLAGEN ; I COLLAGEN ; GELLAN GUM ; CHITOSAN |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| WOS记录号 | WOS:000445170200006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24549 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 作者单位 | 1.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Mingchao,Li, Jie,Li, Wenjun,et al. Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,118(A):41-48. |
| APA | Wang, Mingchao,Li, Jie,Li, Wenjun,Du, Zhenning,&Qin, Song.(2018).Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,118(A),41-48. |
| MLA | Wang, Mingchao,et al."Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 118.A(2018):41-48. |
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