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Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods
Wang, Y; Wang, YQ; Wang, WH; Sun, KX; Chen, LX; Sun, KX (reprint author), Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China.; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. Email:yqwang@yic.ac.cn; sunkx@ytu.edu.cn; lxchen@yic.ac.cn
2016-10-19
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume8Issue:41Pages:28105-28115
Contribution Rank[Wang, Yuan; Sun, Kaoxiang] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China; [Wang, Yuan; Wang, Yunqing; Wang, Wenhai; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
AbstractReporter-embedded (RE) tags are a generation of sensitive, stable surface: enhanced Raman scattering (SERB), tags with Raman reporters embedded between gold nano article(NP) core and gold (or silver), shells. Most of the reported RE tags have b-een designed using: Au nanospheres as a seed material. Herein, we investigated the: synthesis and SERS properties of AuNR/reporter/Ag tags by using gold nanorod (AuNR) seeds witk,ariisotropic physical and optical features. Several highlighted points discovered, including the following: (1) The cetyltrimethyl ammonium bromide (CTAB) layer induced the coexistence of chemically and physically adsorbed RaMan reporters on AuNR Conventional washing of the Atil TR-reporter complek with water results in the formation of an "internal external" mixed tag. To obtain a "pure" RE structure, an additional extraction step involving a CTAB solution was essential. (2) The anisotropic distribution of CTAB on AuNR resulted in the preference of the Raman reporters to adsorb to the hotspot at the AuNR tip, which made it a perfect match for improving the SERS signal of the tag. (3) An.anisotropic silver coating occurred with the shell thickness on the AuNThside-growing much faster than the shell"thianess at the tip. This feature ensured that the tag grew to a suitable size with enough silVer for SERS enhancement without shadowing the effective Raman reporters at the tip too much. (4) RE tags showed better in vitro and in vivo signal stabilities compared with their external labeling counterparts. Moreover, a novel pH-sensitive SERS peak test was proposed by using 4-mercaptobenzoic acid as the Raman reporter to verify thin coverage by a silver layer. We believe this tag can be broadly applied for molecular detection and bioimaging, and the proposed preparation and structure verification methods can provide universal guidance in the design of novel RE tags.
KeywordGold Nanorod Sers Tags Internal Standard Core-shell Nanoparticle Anisotropic Property
Department中科院海岸带环境过程与生态修复重点实验室
DOI10.1021/acsami.6b04216
Funding OrganizationNational Natural Science Foundation of China(81573393 ; 12th Five Years Key Programs for Science and Technology Development of China(2013ZX09402201) ; Natural Science Foundation of Shandong(ZR2014HM062 ; Science and Technology Development Plan of Shandong Province of China(2014GGF01074) ; 21305157 ; ZR2013HQ009) ; 81102415 ; 21575159)
Indexed BySCI
WOS KeywordENHANCED RAMAN-SCATTERING ; CORE-SHELL NANOPARTICLES ; SILVER NANOPARTICLES ; INTERNAL REFERENCE ; GROWTH METHOD ; NANOSTRUCTURES ; DISSOLUTION ; PARTICLES ; TOXICITY ; LAYER
SubtypeArticle
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS IDWOS:000385992400077
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/17463
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorWang, YQ; Sun, KX (reprint author), Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China.; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. Email:yqwang@yic.ac.cn; sunkx@ytu.edu.cn; lxchen@yic.ac.cn
Recommended Citation
GB/T 7714
Wang, Y,Wang, YQ,Wang, WH,et al. Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(41):28105-28115.
APA Wang, Y.,Wang, YQ.,Wang, WH.,Sun, KX.,Chen, LX.,...&lxchen@yic.ac.cn.(2016).Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods.ACS APPLIED MATERIALS & INTERFACES,8(41),28105-28115.
MLA Wang, Y,et al."Reporter-Embedded SERS Tags from Gold Nanorod Seeds: Selective Immobilization of Reporter Molecules at the Tip of Nanorods".ACS APPLIED MATERIALS & INTERFACES 8.41(2016):28105-28115.
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