YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
Alternative TitleSmall-molecular Fluorescent Probes for the Detection of Hydrogen Polysulfides and Nitroxyl
张鹏; 韩潇玥; 于法标; 陈令新; 于法标,中国科学院烟台海岸带研究所,曲阜师范大学化学与化工学院,E-mail:fbyu@yic.ac.cn; 陈令新,中国科学院烟台海岸带研究所,曲阜师范大学化学与化工学院,E-mail:lxchen@yic.ac.cn
Source Publication影像科学与光化学
Contribution Rank曲阜师范大学化学与化工学院;中国科学院烟台海岸带研究所;中国科学院大学;
Other AbstractHydrogen polysulfides(H2Sn)and nitroxyl(HNO)play important roles in a series of physiological and pathological processes,including regulating intracellular redox signaling processes,strengthening myocardial contractility and inhibiting platelet aggregation.H2 Sn can be formed by the reaction between hydrogen sulfide(H2S)and reactive oxygen species.Nitric oxide(NO)and HNO can interconvert in the present of superoxide dismutase.H2 S can react with NO and form H2 Sn and HNO,which will alter the enzymatic activity and protein protein interactions,and then affect protein functions.Therefore,the capability to real-time detect the concentrations of H2 Snand HNO in vivo are of great significance in biomedical research area.Among the various bioanalysis methods,the fluorescent probe technology with the advantages of good selectivity,high sensitivity,real-time in situ detection and negligible damage to sample,has received widespread attention.This review classifies and summarizes the fluorescent probes which are developed in recent years to detect H2 Snand HNO concentrations based on the reaction types between the response units and the analytes.This review mainly focus on elaborating the design concepts,detection mechanisms and biological applications of these probes.Finally,the application prospect of fluorescent probes are discussed.At the same time,this review also cover the fluorescence probes for the detection of hydrogen sulfide and other sulfane sulfur.
Keyword荧光探针 多硫化氢 亚硝酰氢 硫化氢 硫烷硫 荧光成像
DOI10.7517 / j.issn.1674-0475.2016.05.040
Funding Organization国家自然科学基金项目((21405172,21575159,21275158) ; 中国科学院青年创新促进会项目(Grant 2015170)资助
Indexed ByCSCD
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Document Type期刊论文
Corresponding Author于法标,中国科学院烟台海岸带研究所,曲阜师范大学化学与化工学院,E-mail:fbyu@yic.ac.cn; 陈令新,中国科学院烟台海岸带研究所,曲阜师范大学化学与化工学院,E-mail:lxchen@yic.ac.cn
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张鹏,韩潇玥,于法标,等. 用于检测多硫化氢和亚硝酰氢的小分子荧光探针[J]. 影像科学与光化学,2016,34(5):402-425.
APA 张鹏,韩潇玥,于法标,陈令新,于法标,中国科学院烟台海岸带研究所,曲阜师范大学化学与化工学院,E-mail:fbyu@yic.ac.cn,&陈令新,中国科学院烟台海岸带研究所,曲阜师范大学化学与化工学院,E-mail:lxchen@yic.ac.cn.(2016).用于检测多硫化氢和亚硝酰氢的小分子荧光探针.影像科学与光化学,34(5),402-425.
MLA 张鹏,et al."用于检测多硫化氢和亚硝酰氢的小分子荧光探针".影像科学与光化学 34.5(2016):402-425.
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