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Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property
Su, XM; Wang, YQ; Wang, WH; Sun, KX; Chen, LX; Sun, KX (reprint author), Yantai Univ, Shandong Univ,Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Yantai 264005, Peoples R China.; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. yqwang@yic.ac.cn; sunkx@ytu.edu.cn; lxchen@yic.ac.cn
2016-04-27
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume8Issue:16Pages:10201-10211
Contribution Rank[Su, Xueming; Sun, Kaoxiang] Yantai Univ, Shandong Univ,Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Yantai 264005, Peoples R China; [Su, Xueming; Wang, Yunqing; Wang, Wenhai; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
AbstractSurface-enhanced Raman scattering (SERS) tags draw much attention due to the ultrasensitivity and multiplex labeling capability. Recently, a new kind of SERS tags was rationally designed by encapsulating metal nano particles with phospholipid bilayers, showing great potential in theranostics. The lipid bilayer coating confers biocompatibility and versatility to changing surface chemistry of the tag; however, its "soft" feature may influence SERS signal stability, which is rarely investigated. Herein, we prepared phospholipid-coated AuNR@Ag/Au nanosphere SERS tags by using three different kinds of Raman reporters, i.e., thio-containing 4-nitrothiophenol (NT), nitrogen-containing hydrophobic chromophore cyanine 7 monoacid (Cy7), and alkyl chain-chromophore conjugate 1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine (DiD). It was found that signal responses were different upon additional stimulation which the tags may encounter in theranostic applications including the presence of detergent Triton X-100; lipid membrane, and photothermal treatment. Living-cell imaging also showed signal changing distinction. The different SERS signal performances were attributed to the different Raman reporter releasing behaviors from the tags. This work revealed that Raman reporter structure determined signal stability of lipid-coated SERS tags, providing guidance for the design of stimulus responsive tags. Moreover, it also implied the potential of SERS technique for real time drug release study of lipid based nanomedicine.
KeywordSurface-enhanced Raman Scattering (Sers) Gold Nanoparticle Lipid Bilayer Signal Stability Cell Imaging
Department中科院海岸带环境过程与生态修复重点实验室
DOI10.1021/acsami.6b01523
Funding OrganizationNational Natural Science Foundation of China(81573393 ; 12th Five Years Key Programs for Science and Technology Development of China(2013ZX09402201) ; Natural Science Foundation of Shandong(ZR2014HM062 ; Science and Technology Development Plan of Shandong Province of China(2014GGF01074) ; 21305157 ; ZR2013HQ009) ; 81102415 ; 21575159)
Indexed BySCI
WOS KeywordENHANCED RAMAN-SCATTERING ; DRUG-DELIVERY ; GOLD NANORODS ; BIOMEDICAL APPLICATIONS ; PLASMONIC NANORATTLES ; COLLOIDAL PARTICLES ; SHELL NANOPARTICLES ; LIPID-BILAYERS ; CANCER-THERAPY ; GROWTH METHOD
SubtypeArticle
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS IDWOS:000375245100017
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/17047
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorWang, YQ; Sun, KX (reprint author), Yantai Univ, Shandong Univ,Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Yantai 264005, Peoples R China.; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. yqwang@yic.ac.cn; sunkx@ytu.edu.cn; lxchen@yic.ac.cn
Affiliation1.Yantai Univ, Shandong Univ,Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat
Recommended Citation
GB/T 7714
Su, XM,Wang, YQ,Wang, WH,et al. Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(16):10201-10211.
APA Su, XM.,Wang, YQ.,Wang, WH.,Sun, KX.,Chen, LX.,...&lxchen@yic.ac.cn.(2016).Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property.ACS APPLIED MATERIALS & INTERFACES,8(16),10201-10211.
MLA Su, XM,et al."Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property".ACS APPLIED MATERIALS & INTERFACES 8.16(2016):10201-10211.
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