[Chen, Lingxin; Wang, Xiaoyan; Lu, Wenhui; Wu, Xiaqing; Li, Jinhua] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Chen, Lingxin] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China; [Chen, Lingxin] Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China; [Wang, Xiaoyan] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
通讯作者:
Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China.
; Chen, LX (reprint author), Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China.
; Chen, LX (reprint author), Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China. lxchen@yic.ac.cn
作者部门:
中科院海岸带环境过程与生态修复重点实验室
英文摘要:
Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined. Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).
研究领域[WOS]:
Chemistry
项目资助者:
National Natural Science Foundation of China(21477160
; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA11020702)
; 21275158
; 21575159)
关键词[WOS]:
SOLID-PHASE EXTRACTION
; PERFORMANCE LIQUID-CHROMATOGRAPHY
; SURFACE-PLASMON RESONANCE
; BAR SORPTIVE EXTRACTION
; BOVINE SERUM-ALBUMIN
; TRANSFER RADICAL POLYMERIZATION
; FRAGMENTATION CHAIN TRANSFER
; TANDEM MASS-SPECTROMETRY
; INJECTION CHEMILUMINESCENCE SENSOR
; QUARTZ-CRYSTAL MICROBALANCE
