SERS-based microdevices for use as <i>in vitro</i> diagnostic biosensors

doi:10.1039/d3cs01055d

YIC-IR

	*SERS-based microdevices for use as in vitro* diagnostic biosensors**
	Lee, Sungwoon 1; Dang, Hajun 1; Moon, Joung-Il 1; Kim, Kihyun 1; Joung, Younju 1; Park, Sohyun 1; Yu, Qian 1; Chen, Jiadong 1; Lu, Mengdan 1; Chen, Lingxin2,3 ; Joo, Sang-Woo 4; Choo, Jaebum 1
发表期刊	CHEMICAL SOCIETY REVIEWS
ISSN	0306-0012
	2024-04-10
页码	34
DOI	10.1039/d3cs01055d
通讯作者	Chen, Lingxin(lxchen@yic.ac.cn) ; Joo, Sang-Woo(sjoo@ssu.ac.kr) ; Choo, Jaebum(jbchoo@cau.ac.kr)
英文摘要	Advances in surface-enhanced Raman scattering (SERS) detection have helped to overcome the limitations of traditional in vitro diagnostic methods, such as fluorescence and chemiluminescence, owing to its high sensitivity and multiplex detection capability. However, for the implementation of SERS detection technology in disease diagnosis, a SERS-based assay platform capable of analyzing clinical samples is essential. Moreover, infectious diseases like COVID-19 require the development of point-of-care (POC) diagnostic technologies that can rapidly and accurately determine infection status. As an effective assay platform, SERS-based bioassays utilize SERS nanotags labeled with protein or DNA receptors on Au or Ag nanoparticles, serving as highly sensitive optical probes. Additionally, a microdevice is necessary as an interface between the target biomolecules and SERS nanotags. This review aims to introduce various microdevices developed for SERS detection, available for POC diagnostics, including LFA strips, microfluidic chips, and microarray chips. Furthermore, the article presents research findings reported in the last 20 years for the SERS-based bioassay of various diseases, such as cancer, cardiovascular diseases, and infectious diseases. Finally, the prospects of SERS bioassays are discussed concerning the integration of SERS-based microdevices and portable Raman readers into POC systems, along with the utilization of artificial intelligence technology.
资助机构	National Natural Science Foundation of China ; National Research Foundation of Korea ; National Natural Science Foundation of China
收录类别	SCI
语种	英语
关键词[WOS]	ENHANCED RAMAN-SCATTERING ; LATERAL FLOW ASSAY ; HIGHLY SENSITIVE DETECTION ; LUNG-CANCER ; ULTRASENSITIVE DETECTION ; PROSTATE-CANCER ; COMPETITIVE IMMUNOASSAY ; DNA OLIGONUCLEOTIDES ; BACTERIAL PATHOGENS ; BIOMARKER DETECTION
研究领域[WOS]	Chemistry
WOS记录号	WOS:001199753100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35346
专题	中国科学院烟台海岸带研究所
通讯作者	Chen, Lingxin; Joo, Sang-Woo; Choo, Jaebum
作者单位	1.Chung Ang Univ, Dept Chem, Seoul 06974, South Korea 2.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 3.Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 4.Soongsil Univ, Dept Informat Commun Mat & Chem Convergence Techno, Seoul 06978, South Korea
推荐引用方式 GB/T 7714	Lee, Sungwoon,Dang, Hajun,Moon, Joung-Il,et al. SERS-based microdevices for use as in vitro diagnostic biosensors[J]. CHEMICAL SOCIETY REVIEWS,2024:34.
APA	Lee, Sungwoon.,Dang, Hajun.,Moon, Joung-Il.,Kim, Kihyun.,Joung, Younju.,...&Choo, Jaebum.(2024).SERS-based microdevices for use as in vitro diagnostic biosensors.CHEMICAL SOCIETY REVIEWS,34.
MLA	Lee, Sungwoon,et al."SERS-based microdevices for use as in vitro diagnostic biosensors".CHEMICAL SOCIETY REVIEWS (2024):34.