Metabolomics revealed more deleterious toxicity induced by the combined exposure of ammonia and nitrite on<i> Ruditapes</i><i> philippinarum</i> compared to single exposure

doi:10.1016/j.marenvres.2024.106398

	Metabolomics revealed more deleterious toxicity induced by the combined exposure of ammonia and nitrite on Ruditapes philippinarum compared to single exposure
	Cong, Ming1 ; Li, Zhaoshun 1; Che, Yu 1; Li, Yuanmei 1; Tian, Wenwen 1; Lv, Jiasen 2; Sun, Xiyan 3
发表期刊	MARINE ENVIRONMENTAL RESEARCH
ISSN	0141-1136
	2024-04-01
卷号	196 页码:11
关键词	Ammonia Nitrite Ruditapes philippinarum Toxicity Metabolomics
DOI	10.1016/j.marenvres.2024.106398
通讯作者	Cong, Ming(mcong@ytu.edu.cn) ; Lv, Jiasen(jslv@ytu.edu.cn)
英文摘要	NH3-N and NO2-N always co-exist in the aquatic environment, but there is not a clear opinion on their joint toxicities to the molluscs. Presently, clams Ruditapes philippinarum were challenged by environmental concentrations of NH3-N and NO2-N, singly or in combination, and analyzed by metabolomics approaches, enzyme assays and transmission electron microscope (TEM) observation. Results showed that some same KEGG pathways with different enriched-metabolites were detected in the three exposed groups within one day, and completely different profiles of metabolites were found in the rest of the exposure period. The combined exposure induced heavier and more lasting toxicities to the clams compared with their single exposure. ACP activity and the number of secondary lysosomes were significantly increased after the combined exposure. The present study shed light on the joint-toxicity mechanism of NH3-N and NO2-N, and provided fundamental data for the toxicity research on inorganic nitrogen.
资助机构	Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China
收录类别	SCI
语种	英语
关键词[WOS]	METHIONINE RESTRICTION ; OXIDATIVE STRESS ; METABOLISM ; POLLUTION ; PATHWAYS ; NITROGEN ; CYSTEINE ; NITRATE ; GROWTH ; DAMAGE
研究领域[WOS]	Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Toxicology
WOS记录号	WOS:001198913600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35290
专题	支撑部门_中国科学院牟平海岸带环境综合试验站
通讯作者	Cong, Ming; Lv, Jiasen
作者单位	1.Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China 2.Yantai Univ, Biol Sch, Yantai 264005, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Cong, Ming,Li, Zhaoshun,Che, Yu,et al. Metabolomics revealed more deleterious toxicity induced by the combined exposure of ammonia and nitrite on Ruditapes philippinarum compared to single exposure[J]. MARINE ENVIRONMENTAL RESEARCH,2024,196:11.
APA	Cong, Ming.,Li, Zhaoshun.,Che, Yu.,Li, Yuanmei.,Tian, Wenwen.,...&Sun, Xiyan.(2024).Metabolomics revealed more deleterious toxicity induced by the combined exposure of ammonia and nitrite on Ruditapes philippinarum compared to single exposure.MARINE ENVIRONMENTAL RESEARCH,196,11.
MLA	Cong, Ming,et al."Metabolomics revealed more deleterious toxicity induced by the combined exposure of ammonia and nitrite on Ruditapes philippinarum compared to single exposure".MARINE ENVIRONMENTAL RESEARCH 196(2024):11.