Metabolomics revealed more deleterious toxicity induced by the combined exposure of ammonia and nitrite on Ruditapes philippinarum compared to single exposure
Cong, Ming1; Li, Zhaoshun1; Che, Yu1; Li, Yuanmei1; Tian, Wenwen1; Lv, Jiasen2; Sun, Xiyan3
发表期刊MARINE ENVIRONMENTAL RESEARCH
ISSN0141-1136
2024-04-01
卷号196页码:11
关键词Ammonia Nitrite Ruditapes philippinarum Toxicity Metabolomics
DOI10.1016/j.marenvres.2024.106398
通讯作者Cong, Ming(mcong@ytu.edu.cn) ; Lv, Jiasen(jslv@ytu.edu.cn)
英文摘要NH3-N and NO2-N always co-exist in the aquatic environment, but there is not a clear opinion on their joint toxicities to the molluscs. Presently, clams Ruditapes philippinarum were challenged by environmental concentrations of NH3-N and NO2-N, singly or in combination, and analyzed by metabolomics approaches, enzyme assays and transmission electron microscope (TEM) observation. Results showed that some same KEGG pathways with different enriched-metabolites were detected in the three exposed groups within one day, and completely different profiles of metabolites were found in the rest of the exposure period. The combined exposure induced heavier and more lasting toxicities to the clams compared with their single exposure. ACP activity and the number of secondary lysosomes were significantly increased after the combined exposure. The present study shed light on the joint-toxicity mechanism of NH3-N and NO2-N, and provided fundamental data for the toxicity research on inorganic nitrogen.
资助机构Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China
收录类别SCI
语种英语
关键词[WOS]METHIONINE RESTRICTION ; OXIDATIVE STRESS ; METABOLISM ; POLLUTION ; PATHWAYS ; NITROGEN ; CYSTEINE ; NITRATE ; GROWTH ; DAMAGE
研究领域[WOS]Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Toxicology
WOS记录号WOS:001198913600001
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/35290
专题支撑部门_中国科学院牟平海岸带环境综合试验站
通讯作者Cong, Ming; Lv, Jiasen
作者单位1.Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China
2.Yantai Univ, Biol Sch, Yantai 264005, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Shandong, Peoples R China
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Cong, Ming,Li, Zhaoshun,Che, Yu,et al. Metabolomics revealed more deleterious toxicity induced by the combined exposure of ammonia and nitrite on Ruditapes philippinarum compared to single exposure[J]. MARINE ENVIRONMENTAL RESEARCH,2024,196:11.
APA Cong, Ming.,Li, Zhaoshun.,Che, Yu.,Li, Yuanmei.,Tian, Wenwen.,...&Sun, Xiyan.(2024).Metabolomics revealed more deleterious toxicity induced by the combined exposure of ammonia and nitrite on Ruditapes philippinarum compared to single exposure.MARINE ENVIRONMENTAL RESEARCH,196,11.
MLA Cong, Ming,et al."Metabolomics revealed more deleterious toxicity induced by the combined exposure of ammonia and nitrite on Ruditapes philippinarum compared to single exposure".MARINE ENVIRONMENTAL RESEARCH 196(2024):11.
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