A polymeric membrane ion-selective electrode for the determination of clenbuterol is described.It is based on a molecularly imprinted polymer（MIP） as an ionophore for molecular recognition,which can be synthesized by precipitation polymerization using clenbuterol hydrochloride as a template molecule.Under the optimized conditions,the proposed membrane electrode exhibits Nernstian response to the protonated clenbuterol over the concentration range of 1.0×10-7-1.0×10-4 mol/L with a slope of 55.7 mV/decade,and the detection limit is 7.0×10-8 mol/L.The MIP-based sensor shows excellent selectivity,rapid response time and satisfactory long-term stability.The potentiometric sensor has been successfully applied to determine the clenbuterol in pig urine samples with recoveries between 98% and 107% and an analytical time of less than 3 min.
; 高奇; 秦伟
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