Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway | |
其他题名 | Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway |
Liu Qi1; Li Wenjun1![]() ![]() ![]() | |
发表期刊 | Journal of Oceanology and Limnology
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ISSN | 2096-5508 |
2019 | |
卷号 | 37期号:5页码:1678-1685 |
关键词 | phycocyanin inflammatory TLR2-MyD88-NF-κB signaling pathway |
英文摘要 | Phycocyanin (PC),a natural algal protein,is reported for having anti-oxidant and antiinflammatory properties.We investigated its ability to attenuate lung inflammation in mice subjected to X-ray radiation.Male C57BL/6 mice were assigned to the control,total body irradiation,PC pretreatment,and PC treatment groups.Mice in the PC pretreatment group were gavaged with 200 mg/kg PC for 7 consecutive days before irradiation,and those in the PC treatment group were gavaged with 200 mg/kg PC for 7 consecutive days after irradiation.Lungs were collected on Day 7 after irradiation exposure.Hematoxylin and eosin staining of mouse lung sections showed considerable inflammation damage 7 days after irradiation compared with the control lung but a reduction in pathological injury in the PC treatment group.Pretreatment or treatment with PC significantly decreased levels of interleukin-6 and tumor necrosis factor-α in the lung,and also increased the relative mRNA expression of superoxide dismutase and glutathione.In vivo,PC significantly reduced the expression of Toll-like receptor TLR2,myeloid differentiation primary response Myd88,and nuclear factor NF-κB,at both the transcriptional and translation level.Taken together,these data indicated that PC attenuated lung inflammatory damage induced by radiation by blocking the TLR2- MyD88-NF-κB signaling pathway.Therefore,PC could be a protective agent against radiation-induced inflammatory damage in normal tissues. |
中文摘要 | Phycocyanin (PC),a natural algal protein,is reported for having anti-oxidant and antiinflammatory properties.We investigated its ability to attenuate lung inflammation in mice subjected to X-ray radiation.Male C57BL/6 mice were assigned to the control,total body irradiation,PC pretreatment,and PC treatment groups.Mice in the PC pretreatment group were gavaged with 200 mg/kg PC for 7 consecutive days before irradiation,and those in the PC treatment group were gavaged with 200 mg/kg PC for 7 consecutive days after irradiation.Lungs were collected on Day 7 after irradiation exposure.Hematoxylin and eosin staining of mouse lung sections showed considerable inflammation damage 7 days after irradiation compared with the control lung but a reduction in pathological injury in the PC treatment group.Pretreatment or treatment with PC significantly decreased levels of interleukin-6 and tumor necrosis factor-α in the lung,and also increased the relative mRNA expression of superoxide dismutase and glutathione.In vivo,PC significantly reduced the expression of Toll-like receptor TLR2,myeloid differentiation primary response Myd88,and nuclear factor NF-κB,at both the transcriptional and translation level.Taken together,these data indicated that PC attenuated lung inflammatory damage induced by radiation by blocking the TLR2- MyD88-NF-κB signaling pathway.Therefore,PC could be a protective agent against radiation-induced inflammatory damage in normal tissues. |
收录类别 | CSCD |
语种 | 英语 |
CSCD记录号 | CSCD:6556057 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/35034 |
专题 | 中国科学院烟台海岸带研究所 |
作者单位 | 1.中国科学院烟台海岸带研究所 2.School of Nuclear Science and Technology,Lanzhou University 3.School of Pharmacy,Yantai University |
推荐引用方式 GB/T 7714 | Liu Qi,Li Wenjun,Lu Lina,et al. Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway[J]. Journal of Oceanology and Limnology,2019,37(5):1678-1685. |
APA | Liu Qi,Li Wenjun,Lu Lina,Liu Bin,Du Zhenning,&Qin Song.(2019).Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway.Journal of Oceanology and Limnology,37(5),1678-1685. |
MLA | Liu Qi,et al."Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway".Journal of Oceanology and Limnology 37.5(2019):1678-1685. |
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