Detection of uridine diphosphate glucuronosyltransferase 1A1 for pancreatic cancer imaging and treatment <i>via</i> a "turn-on" fluorescent probe

doi:10.1039/d4an00035h

YIC-IR

	*Detection of uridine diphosphate glucuronosyltransferase 1A1 for pancreatic cancer imaging and treatment via* a "turn-on" fluorescent probe**
	Wang, Lingxiao 1; Wang, Lingyun 4; Sun, Xiao 1; Fu, Lili 1,2; Wang, Xinlei 1; Wang, Xiaoyan 1,2; Chen, Lingxin1,2,3 ; Huang, Yan 1,2
发表期刊	ANALYST
ISSN	0003-2654
	2024-03-23
页码	10
DOI	10.1039/d4an00035h
通讯作者	Chen, Lingxin(lxchen@yic.ac.cn) ; Huang, Yan(yhuang@yic.ac.cn)
英文摘要	Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) is expressed ubiquitously in cancer cells and can metabolize exogenous substances. Studies show higher UGT1A1 levels in pancreatic cancer cells than normal cells. Therefore, we need a method to monitor the activity level of UGT1A1 in pancreatic cancer cells and in vivo. Here, we report a fluorescent probe, BCy-panc, for UGT1A1 imaging in cells and in vivo. Compared with other molecular probes, this probe is readily prepared, with high selectivity and sensitivity for the detection of UGT1A1. Our results show that BCy-panc rapidly detects UGT1A1 in pancreatic cancer. In addition, there is an urgent need for evidence to clarify the relationship between UGT1A1 and pancreatic cancer development. The present investigation found that the increase of UGT1A1 by chrysin was effective in inducing apoptosis in pancreatic cancer cells. These results indicate that the synergistic effect of chrysin and cisplatin at the cellular level is superior to that of cisplatin alone. The UGT1A1 level may be a biomarker for early diagnosis of cancer. Meanwhile, UGT1A1 plays a crucial role in pancreatic cancer, and the combination of chrysin and cisplatin may provide effective ideas for pancreatic cancer treatment.
资助机构	National Natural Science Foundation of China ; National Nature Science Foundation of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding ; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization
收录类别	SCI
语种	英语
关键词[WOS]	UDP-GLUCURONOSYLTRANSFERASES ; HUMAN LIVER ; GLUCURONIDATION ; INHIBITION ; STRATEGIES ; MICROSOMES ; DIAGNOSIS ; UGT1A1 ; MARKER
研究领域[WOS]	Chemistry
WOS记录号	WOS:001196232300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/34940
专题	中国科学院烟台海岸带研究所
通讯作者	Chen, Lingxin; Huang, Yan
作者单位	1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 4.Jinan Zhangqiu Dist Peoples Hosp, Jinan 250000, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lingxiao,Wang, Lingyun,Sun, Xiao,et al. Detection of uridine diphosphate glucuronosyltransferase 1A1 for pancreatic cancer imaging and treatment via a "turn-on" fluorescent probe[J]. ANALYST,2024:10.
APA	Wang, Lingxiao.,Wang, Lingyun.,Sun, Xiao.,Fu, Lili.,Wang, Xinlei.,...&Huang, Yan.(2024).Detection of uridine diphosphate glucuronosyltransferase 1A1 for pancreatic cancer imaging and treatment via a "turn-on" fluorescent probe.ANALYST,10.
MLA	Wang, Lingxiao,et al."Detection of uridine diphosphate glucuronosyltransferase 1A1 for pancreatic cancer imaging and treatment via a "turn-on" fluorescent probe".ANALYST (2024):10.