YIC-IR
Whole-Genome Re-sequencing and Transcriptome Reveal Candidate Genes and Pathways Associated with Hybrid Sterility in Hermaphroditic Argopecten Scallops
Yu, Tieying1,2; Ning, Junhao1; Wang, Fukai3; Liu, Guilong4; Wang, Quanchao1; Xu, Xin4; Wang, Chunde1,2,3; Lu, Xia1
Source PublicationMARINE BIOTECHNOLOGY
ISSN1436-2228
2023-12-01
Volume25Issue:6Pages:891-906
KeywordHermaphroditic Argopecten scallops Hybrid sterility Gametogenesis Meiosis and mitosis Apoptosis
DOI10.1007/s10126-023-10247-y
Corresponding AuthorLu, Xia(xialu@yic.ac.cn)
AbstractThe interspecific hybrid scallops generated from the hermaphroditic bay scallops (Argopecten irradians) and Peruvian scal-lops (Argopecten purpuratus) showed significant heterosis in growth. However, its sterility limits large-scale hybridization and hinders the development of the scallop breeding industry. Hybrid sterility is regulated by plenty of genes and involves a range of biochemical and physiological transformations. In this study, whole-genome re-sequencing and transcriptomic analysis were performed in sterile and fertile hybrid scallops. The potential genetic variations and abnormally expressed genes were detected to explore the mechanism underlying hybrid sterility in hermaphroditic Argopecten scallops. Compared with fertile hybrids, 24 differentially expressed genes (DEGs) with 246 variations were identified to be related to fertility regulation, which were mainly enriched in germarium-derived egg chamber formation, spermatogenesis, spermatid develop-ment, mismatch repair, mitotic and meiotic cell cycles, Wnt signaling pathway, MAPK signaling pathway, calcium modu-lating pathway, and notch signaling pathway. Specifically, variation and abnormal expression of these genes might inhibit the progress of mitosis and meiosis, promote cell apoptosis, and impede the genesis and maturation of gametes in sterile hybrid scallops. Eleven DEGs (XIAP, KAZN, CDC42, MEIS1, SETD1B, NOTCH2, TRPV5, M-EXO1, GGT1, SBDS, and TBCEL) were confirmed by qRT-PCR validation. Our findings may enrich the determination mechanism of hybrid sterility and provide new insights into the use of interspecific hybrids for extensive breeding.
Funding Organizationthe National Natural Science Foundation of China
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Marine & Freshwater Biology
WOS IDWOS:001126612200009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/34870
Collection中国科学院烟台海岸带研究所
Corresponding AuthorLu, Xia
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
4.Yantai Spring Sea AquaSeed Ltd, Yantai 264006, Peoples R China
Recommended Citation
GB/T 7714
Yu, Tieying,Ning, Junhao,Wang, Fukai,et al. Whole-Genome Re-sequencing and Transcriptome Reveal Candidate Genes and Pathways Associated with Hybrid Sterility in Hermaphroditic Argopecten Scallops[J]. MARINE BIOTECHNOLOGY,2023,25(6):891-906.
APA Yu, Tieying.,Ning, Junhao.,Wang, Fukai.,Liu, Guilong.,Wang, Quanchao.,...&Lu, Xia.(2023).Whole-Genome Re-sequencing and Transcriptome Reveal Candidate Genes and Pathways Associated with Hybrid Sterility in Hermaphroditic Argopecten Scallops.MARINE BIOTECHNOLOGY,25(6),891-906.
MLA Yu, Tieying,et al."Whole-Genome Re-sequencing and Transcriptome Reveal Candidate Genes and Pathways Associated with Hybrid Sterility in Hermaphroditic Argopecten Scallops".MARINE BIOTECHNOLOGY 25.6(2023):891-906.
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