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Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians
Zhang, Tianyu1,2,3; Wang, Xin1,2,3; Zhang, Qianqian1,2; Yang, Dinglong1,2; Zhang, Xiaoli1,2; Liu, Hui1,2; Dong, Zhijun1,2; Zhao, Jianmin1,2,4
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
2024-02-20
Volume912Pages:14
KeywordAntibiotics residues Ocean acidification Physiological response Metabolomics Bay scallop
DOI10.1016/j.scitotenv.2023.168941
Corresponding AuthorZhao, Jianmin(jmzhao@yic.ac.cn)
AbstractCoastal areas are confronted with compounding threats arising from both climatic and non-climatic stressors. Antibiotic pollution and ocean acidification are two prevalently concurrent environmental stressors. Yet their interactive effects on marine biota have not been investigated adequately and the compound hazard remain obscure. In this study, bay scallops Argopecten irradians irradians were exposed to multiple antibiotics (sulfamethoxazole, tetracycline, oxytetracycline, norfloxacin, and erythromycin, each at a concentration of 1 mu g/L) combined with/without acidic seawater (pH 7.6) for 35 days. The single and interactive effects of the two stressors on A. irradians irradians were determined from multidimensional bio-responses, including energetic physiological traits as well as the molecular underpinning (metabolome and expressions of key genes). Results showed that multiple antibiotics predominantly enhanced the process of DNA repair and replication via disturbing the purine metabolism pathway. This alternation is perhaps to cope with the DNA damage induced by oxidative stress. Ocean acidification mainly disrupted energy metabolism and ammonia metabolism of the scallops, as evidenced by the increased ammonia excretion rate, the decreased O:N ratio, and perturbations in amino acid metabolism pathways. Moreover, the antagonistic effects of multiple antibiotics and ocean acidification caused alternations in the relative abundance of neurotransmitter and gene expression of neurotransmitter receptors, which may lead to neurological disorders in scallops. Overall, the revealed alternations in physiological traits, metabolites and gene expressions provide insightful information for the health status of bivalves in a natural environmental condition under the climate change scenarios.
Funding OrganizationStrategic Priority Research Program of the Chinese Academy of Sciences ; National Science & Technology Fundamental Resources Investigation Program of China ; Seed Project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences ; Youth Innovation Promotion Association, Chinese Academy of Sciences
Indexed BySCI
Language英语
WOS KeywordOXIDATIVE STRESS ; SEASONAL-VARIATION ; RESISTANCE GENES ; COASTAL WATER ; DNA ; MUSSELS ; RESPONSES ; TOXICITY ; ACID ; SEA
WOS Research AreaEnvironmental Sciences & Ecology
WOS IDWOS:001133719600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/34363
Collection海岸带生物学与生物资源利用重点实验室
支撑部门_中国科学院牟平海岸带环境综合试验站
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorZhao, Jianmin
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resources Utilizat, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc & Ecol Remediat, Yantai 264117, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Tianyu,Wang, Xin,Zhang, Qianqian,et al. Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,912:14.
APA Zhang, Tianyu.,Wang, Xin.,Zhang, Qianqian.,Yang, Dinglong.,Zhang, Xiaoli.,...&Zhao, Jianmin.(2024).Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians.SCIENCE OF THE TOTAL ENVIRONMENT,912,14.
MLA Zhang, Tianyu,et al."Interactive effects of multiple antibiotic residues and ocean acidification on physiology and metabolome of the bay scallops Argopecten irradians irradians".SCIENCE OF THE TOTAL ENVIRONMENT 912(2024):14.
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