The invention relates to the field of insecticidal drugs, in particular to a seaweed polyether compound and a preparation method and an application thereof. The seaweed polyether compound is as shown in the specific structural formula (I), and the preparation method comprises the steps of washing laurencia saitoi perestenko of marine red alga clean with seawater, removing gravels and miscellaneous algae attached on the surface, drying in the shade, smashing, then leaching, carrying out solvent distribution and repeated chromatographic separation and obtaining a monomer compound. The obtained compound can be used as the drug which is used as a pesticide. Furthermore, the natural structure of the polyether compound extracted, separated and purified from the laurencia saitoi perestenko of the marine red alga belongs to a micromolecular natural organic compound, and the seaweed polyether compound is easily prepared, has significant insecticidal activity and can be used as the insecticidaldrug. In the structural formula (I), R is equal to OH or OAc.
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