The invention relates to the daily chemical field and the medical industry, and particularly relates to aminopyridine type acetyl synanthrin and a preparation method thereof. The structural formula of the aminopyridine type acetyl synanthrin is as shown in formula (1) in the specification. The preparation method comprises the following steps : firstly, reacting synanthrin with chloroacetyl chloride, then reacting with aminopyridine, and purifying to finally obtain the aminopyridine type acetyl synanthrin as shown in the formula (1), wherein the molar weight of chloroacetyl chloride is 1-2 times that of the synanthrin; the molar weight ratio of the aminopyridine to acetyl synanthrin is (2-3) : 1. According to the aminopyridine type acetyl synanthrin and the preparation method provided by the invention, the reaction is simple and convenient, high efficiency is realized, promotion is easy to implement, and required equipment and raw materials are easy to get. A research shows that the derivative has good water solubility and remarkable antioxidant activity, improves the biological activity of the synanthrin, widens the application range of the synanthrin, and can be widely applied to the daily chemical and medical fields.
; 胡云霞
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