The invention relates to daily chemical field and pharmaceutical industry, and concretely relates to chitosan bipyridyl quaternary ammonium salts, and a preparation method and application thererof. The chitosan bipyridyl quaternary ammonium salt derivatives qcts2Py, qcts3Py or qcts4Py shown as a formula (1), (2) or (3). The preparation method comprises : taking chitosan as a raw material, reacting with excessive corresponding pyridine aldehyde, so as to synthesize a corresponding Schiff alkali, then reducing by using sodium borohydride to obtain N-substituted chitosan, and then reacting with iodomethane, so as to obtain the chitosan bipyridyl quaternary ammonium salt derivative. Compared with the chitosan raw material, the chitosan bipyridyl quaternary ammonium salt derivatives have good anti-oxidation activity. The chitosan bipyridyl quaternary ammonium salt derivatives are synthesized through the effective synthetic means, also the chitosan bipyridyl quaternary ammonium salt derivatives are relatively good in water solubility and substantially improved in anti-oxidation activity, helps to enhance the bioactivity of chitosan and expand the application scope of chitosan, and are applicable to fields of daily chemicals, pharmaceutical industries and the like.
; 郭占勇
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