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Effects of glyphosate exposure on gut-liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus)
Yan, Biao1,2,3; Sun, Yumiao1,2; Fu, Kaiyu1,2; Zhang, Yindan1,2; Lei, Lei1,2; Men, Jun4; Guo, Yongyong1; Wu, Shengmin5; Han, Jian1,6; Zhou, Bingsheng1
KeywordGlyphosate Metabolomics Grass carp Gut-Liver axis
Corresponding AuthorWu, Shengmin(wsm@nies.org) ; Han, Jian(hanjian@ihb.ac.cn)
AbstractGlyphosate, one of the most widely used herbicide worldwide, is potentially harmful to non-target aquatic organisms. However, the environmental health risks regarding impacts on metabolism homeostasis and underlying mechanisms remain unclear. Here we investigated bioaccumulation, metabolism disorders and mechanisms in grass carp after exposure to glyphosate. Higher accumulation of glyphosate and its major metabolite, aminomethylphosphonic acid, in the gut was detected. Intestinal inflammation, barrier damage and hepatic steatosis were caused by glyphosate exposure. Lipid metabolism disorder was confirmed by the decreased triglyceride, increased total cholesterol and lipoproteins in serum and decreased visceral fat. Metabolomics analysis found that glyphosate exposure significantly inhibited bile acids biosynthesis in liver with decreased total bile acids content, which was further supported by significant downregulations of cyp27a1, cyp8b1 and fxr. Moreover, the dysbiosis of gut microbiota contributed to the inflammation in liver and gut by increasing lipopolysaccharide, as well as to the declined bile acids circulation by reducing secondary bile acids. These results indicated that exposure to environmental levels of glyphosate generated higher bioaccumulation in gut, where evokedenterohepatic injury, intestinal microbiota dysbiosis and disturbed homeostasis of bile acids metabolism; then the functional dysregulation of the gut-liver axis possibly resulted in ultimate lipid metabolism disorder. These findings highlight the metabolism health risks of glyphosate exposure to fish in aquatic environment.
Funding OrganizationOpen Project of State Environmental Protection Key Laboratory of Pesticide Environmental Assessment and Pollution Control ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology
Indexed BySCI
WOS Research AreaEnvironmental Sciences & Ecology
WOS IDWOS:001058033800001
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWu, Shengmin; Han, Jian
Affiliation1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Hubei Univ Sci & Technol, Xianning Med Coll, Xianning Engn Res Ctr Hlth Environm, Xianning 437100, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, Anal & Testing Ctr, Wuhan 430072, Peoples R China
5.Minist Ecol & Environm, Nanjing Inst Environm Sci, Nanjing 210042, Peoples R China
6.Chinese Acad Sci, Inst Hydrobiol, Donghu South Rd, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Yan, Biao,Sun, Yumiao,Fu, Kaiyu,et al. Effects of glyphosate exposure on gut-liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus)[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2023,902:12.
APA Yan, Biao.,Sun, Yumiao.,Fu, Kaiyu.,Zhang, Yindan.,Lei, Lei.,...&Zhou, Bingsheng.(2023).Effects of glyphosate exposure on gut-liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus).SCIENCE OF THE TOTAL ENVIRONMENT,902,12.
MLA Yan, Biao,et al."Effects of glyphosate exposure on gut-liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus)".SCIENCE OF THE TOTAL ENVIRONMENT 902(2023):12.
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