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Hybrid sterility in hermaphroditic Argopecten scallops: Mutated mitochondrial genes and abnormal expression of nuclear genes
Yu, Tieying1,3; Ning, Junhao1; Chen, Min1; Wang, Yuan1,3; Liu, Guilong4; Wang, Quanchao1; Xu, Xin4; Wang, Chunde1,2,3; Lu, Xia1,5
Source PublicationAQUACULTURE REPORTS
ISSN2352-5134
2023-08-01
Volume31Pages:12
KeywordHermaphroditic Argopecten scallops Hybrid sterility MtDNA mutation Energy deficiency Gene expression
DOI10.1016/j.aqrep.2023.101652
Corresponding AuthorLu, Xia(xialu@yic.ac.cn)
AbstractBay scallops (Argopecten irradians) are a commercially important bivalve species for fisheries and aquaculture in China, the USA, Peru and Chile, but their small size and serious inbreeding depression restrict the sustainable development of their aquaculture. We successfully hybridized bay scallops with Peruvian scallops (Argopecten purpuratus), and the F1 hybrids showed significant heterosis in growth, but the majority of them were sterile. Nevertheless, Argopecten scallops are typical hermaphroditic animals, resulting in a low proportion of interspecific hybrids. Hybrid sterility restricts the utilization of Argopecten scallop resources and causes reproductive isolation in speciation. However, the underlying mechanism of hybrid sterility remains unexplored in hermaphroditic scallops. In this study, we investigated the mechanism of hybrid sterility in hermaphroditic Argopecten scallops by examining mutations in mitochondrial genes and the expression of nuclear genes. Our results showed that the ATP content in the gonads of F1 hybrid scallops was significantly lower than that in their parents, indicating that energy deficiency may be an immediate cause of sterility in F1 hybrid scallops. Thirteen SNPs were detected in five mitochondrial genes of F1 hybrids, and 92.3% of which were transitions that could change the hydrophobicity of amino acids and protein structures, and the allele frequencies of the SNP loci were significantly different between sterile hybrids and fertile scallops. Abnormal interaction between the mitochondrial and nuclear genes might contribute to hybrid sterility through the following pathways: (1) inhibition of oocyte maturation by enhanced expression of Mfn2; (2) cell cycle arrest in G1 phase of oocytes by inhibited expression of CDK2; (3) cell apoptosis induced by mitochondrial apoptosis; (4) insufficient energy supply from abnormal mitochondria, and (5) mitochondrial dysfunction resulting from abnormal expression of other nuclear genes. The present results provide more information for understanding the mechanism of hybrid sterility in hermaphroditic animals and benefit extensive hybrid breeding.
Funding OrganizationNational Natural Science Foundation of China ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province ; Scientific and Technological Project of Yantai, Shandong Province ; Ear-marked Fund for Shandong Modern Agro-Industry Technology Research System ; Science and technology smes innovation capacity improvement project in Shandong Province
Indexed BySCI
Language英语
WOS KeywordDOUBLY UNIPARENTAL INHERITANCE ; BAY SCALLOP ; INBREEDING DEPRESSION ; CELL-DEATH ; TRAITS ; DEFECTS ; MTDNA
WOS Research AreaFisheries
WOS IDWOS:001039983700001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/33400
Collection海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorLu, Xia
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Shandong, Peoples R China
2.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Yantai Spring Sea AquaSeed Ltd, Yantai 264006, Peoples R China
5.17 Chunhui Rd, Yantai, Peoples R China
Recommended Citation
GB/T 7714
Yu, Tieying,Ning, Junhao,Chen, Min,et al. Hybrid sterility in hermaphroditic Argopecten scallops: Mutated mitochondrial genes and abnormal expression of nuclear genes[J]. AQUACULTURE REPORTS,2023,31:12.
APA Yu, Tieying.,Ning, Junhao.,Chen, Min.,Wang, Yuan.,Liu, Guilong.,...&Lu, Xia.(2023).Hybrid sterility in hermaphroditic Argopecten scallops: Mutated mitochondrial genes and abnormal expression of nuclear genes.AQUACULTURE REPORTS,31,12.
MLA Yu, Tieying,et al."Hybrid sterility in hermaphroditic Argopecten scallops: Mutated mitochondrial genes and abnormal expression of nuclear genes".AQUACULTURE REPORTS 31(2023):12.
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