Lipids and Terpenoids from the Deep-Sea Fungus <i>Trichoderma lixii</i> R22 and Their Antagonism against Two Wheat Pathogens

doi:10.3390/molecules28176220

	*Lipids and Terpenoids from the Deep-Sea Fungus Trichoderma lixii* R22 and Their Antagonism against Two Wheat Pathogens**
	Li, Chang-Peng 1,2; Shi, Zhen-Zhen 1; Fang, Sheng-Tao1 ; Song, Yin-Ping 1; Ji, Nai-Yun1,2,3
发表期刊	MOLECULES
	2023-09-01
卷号	28 期号:17 页码:10
关键词	Trichoderma lipid terpenoid butenolide brasilane fungicide
DOI	10.3390/molecules28176220
通讯作者	Ji, Nai-Yun(nyji@yic.ac.cn)
英文摘要	Five new lipids, tricholixins A-E (1-5), and two known terpenoids, brasilane A (6) and harzianone A (7), were discovered from a deep-sea strain (R22) of the fungus Trichoderma lixii isolated from the cold seep sediments of the South China Sea. Their structures and relative configurations were identified by meticulous analysis of MS and IR as well as NMR data. The absolute configuration of 5 was ascertained by dimolybdenum-induced ECD data in particular. Compounds 1 and 2 represent the only two new butenolides from marine-derived Trichoderma, and they further add to the structural diversity of these molecules. Although 6 has been reported from a basidiomycete previously, it is the first brasilane aminoglycoside of Trichoderma origin. During the assay against wheat-pathogenic fungi, both 1 and 2 inhibited Fusarium graminearum with an MIC value of 25.0 mu g/mL, and 6 suppressed Gaeumannomyces graminis with an MIC value of 12.5 mu g/mL. Moreover, the three isolates also showed low toxicity to the brine shrimp Artemia salina.
资助机构	The authors acknowledgment Xiu-Li Yin and Ke Li (Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences) for their technical support of NMR and HRESIMS. ; Yantai Institute of Coastal Zone Research
收录类别	SCI
语种	英语
关键词[WOS]	SECONDARY METABOLITES ; DERIVATIVES ; ANTIBIOTICS ; ANTIFUNGAL ; CULTURES ; STRAINS ; ALGA
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
WOS记录号	WOS:001070077900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32879
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Ji, Nai-Yun
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shandong Saline Alkaline Land Modern Agr Co, Dongying 257345, Peoples R China
推荐引用方式 GB/T 7714	Li, Chang-Peng,Shi, Zhen-Zhen,Fang, Sheng-Tao,et al. Lipids and Terpenoids from the Deep-Sea Fungus Trichoderma lixii R22 and Their Antagonism against Two Wheat Pathogens[J]. MOLECULES,2023,28(17):10.
APA	Li, Chang-Peng,Shi, Zhen-Zhen,Fang, Sheng-Tao,Song, Yin-Ping,&Ji, Nai-Yun.(2023).Lipids and Terpenoids from the Deep-Sea Fungus Trichoderma lixii R22 and Their Antagonism against Two Wheat Pathogens.MOLECULES,28(17),10.
MLA	Li, Chang-Peng,et al."Lipids and Terpenoids from the Deep-Sea Fungus Trichoderma lixii R22 and Their Antagonism against Two Wheat Pathogens".MOLECULES 28.17(2023):10.