A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic <i>Trichoderma</i> sp. Z43

doi:10.1002/cbdv.202301099

	*A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic Trichoderma* sp. Z43**
	Shi, Zhen-Zhen 1; Yin, Xiu-Li1 ; Song, Yin-Ping 1; Ji, Nai-Yun1,2
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
	2023-09-20
页码	5
关键词	antimicroalgal activity harziane diterpene steroid structure elucidation Trichoderma
DOI	10.1002/cbdv.202301099
通讯作者	Ji, Nai-Yun(nyji@yic.ac.cn)
英文摘要	One new diterpene, harziaketal A (1), and one new highly degraded sterol, trichosterol A (2), along with three known compounds, including one diterpene, harzianone (3), and two steroids, (22E,24R)-5 alpha,6 alpha-epoxy-ergosta-8(14),22-dien-3 ss,7 alpha-diol (4) and isoergokonin B (5), were isolated from the culture of the marine-alga-epiphytic fungus Trichoderma sp. Z43 by silica gel column chromatography (CC), Sephadex LH-20 CC, and preparative thin-layer chromatography (TLC). Their structures and relative configurations were assigned by nuclear magnetic resonance (NMR) and high resolution electrospray ionisation mass spectrometry (HR-ESI-MS) data, and the absolute configuration of 1 was established by X-ray diffraction. Compound 1 features a hemiketal unit situated at the four-membered ring of harziane-type diterpenes for the first time, while 2 represents the rare occurrence of sterols with rings A and B being degraded. Compounds 1 and 2 displayed weak inhibition against the tested phytoplankton (Amphidinium carterae, Heterocapsa circularisquama, Heterosigma akashiwo, and Prorocentrum donghaiense) with half maximal inhibitory concentration (IC50) ranging from 14 to 53 mu g/mL.
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province ; Taishan Scholar Project Special Funding ; Youth Innovation Promotion Association of the CAS
收录类别	SCI
语种	英语
关键词[WOS]	DEGRADED STEROLS ; INCISTEROLS
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
WOS记录号	WOS:001068392300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32870
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Ji, Nai-Yun
作者单位	1.Chinese Acad Sci, Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Shandong Saline Alkaline Land Modern Agr Co, Dongying 257345, Peoples R China
推荐引用方式 GB/T 7714	Shi, Zhen-Zhen,Yin, Xiu-Li,Song, Yin-Ping,et al. A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic Trichoderma sp. Z43[J]. CHEMISTRY & BIODIVERSITY,2023:5.
APA	Shi, Zhen-Zhen,Yin, Xiu-Li,Song, Yin-Ping,&Ji, Nai-Yun.(2023).A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic Trichoderma sp. Z43.CHEMISTRY & BIODIVERSITY,5.
MLA	Shi, Zhen-Zhen,et al."A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic Trichoderma sp. Z43".CHEMISTRY & BIODIVERSITY (2023):5.