New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus<i> Aspergillus</i> sp.

doi:10.1016/j.fitote.2023.105659

	New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus Aspergillus sp.
	Fang, Sheng-Tao; Shi, Zhen-Zhen; Song, Yin-Ping; Yin, Xiu-Li; Ji, Nai-Yun
发表期刊	FITOTERAPIA
ISSN	0367-326X
	2023-10-01
卷号	170 页码:6
关键词	Marine fungus Aspergillus Ophiobolin sesterterpenoid Drimane sesquiterpenoid Anti-microalgal activity
DOI	10.1016/j.fitote.2023.105659
通讯作者	Ji, Nai-Yun(nyji@yic.ac.cn)
英文摘要	Further investigation of secondary metabolites of a marine-alga-derived fungus Aspergillus sp. RR-YLW-12 led to isolate one new ophiobolin-type sesterterpenoid (1), four new drimane-type sesquiterpenoids (2-5) and one natural occurring compound (6), together with seven known compounds (7-13). Their structures and stereo chemistry were elucidated by extensive spectroscopic analysis of NMR and HRMS experiments, and by comparison with the literature data. All isolates were evaluated for growth inhibition of five marine harmful microalgae. The new compounds exhibited significant to moderate inhibitory effects towards all tested micro algae species with IC50 values ranging from 5.8 to 54.5 & mu;g/mL.
资助机构	Promotion Association of the CAS ; Taishan Scholar Project Special Funding
收录类别	SCI
语种	英语
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:001072059600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32858
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Ji, Nai-Yun
作者单位	Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Fang, Sheng-Tao,Shi, Zhen-Zhen,Song, Yin-Ping,et al. New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus Aspergillus sp.[J]. FITOTERAPIA,2023,170:6.
APA	Fang, Sheng-Tao,Shi, Zhen-Zhen,Song, Yin-Ping,Yin, Xiu-Li,&Ji, Nai-Yun.(2023).New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus Aspergillus sp..FITOTERAPIA,170,6.
MLA	Fang, Sheng-Tao,et al."New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus Aspergillus sp.".FITOTERAPIA 170(2023):6.