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Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment
Li, Qing1; Yang, Yunhui1,2; Li, Yijian3; Mi, Yingqi1,5; Ma, Xuanxuan4; Jiang, Aili2; Guo, Zhanyong1
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
2023-12-31
Volume253Pages:13
KeywordPolysaccharide Chemical modification Coumarins
DOI10.1016/j.ijbiomac.2023.126691
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
AbstractNatural polysaccharides are abundant and renewable resource, but their applications are hampered by limited biological activity. Chemical modification can overcome these drawbacks by altering their structure. Three series of polysaccharide derivatives with coumarins were synthesized to obtain polysaccharide derivatives with enhanced biological activity. The biological activities were tested, including antioxidant property, antifungal property, and antibacterial property. Based on the results, the inhibitory properties of the coumarin-polysaccharide derivatives were significantly improved over the raw polysaccharide. The IC50 of the inhibition of DPPH, ABTS(center dot+), and superoxide (O-2(center dot-)) radical-scavenging was 0.06-0.15 mg/mL, 2.3-15.9 mu g/mL, and 0.03-0.25 mg/mL, respectively. Compared with the raw polysaccharides, coumarin-polysaccharide derivatives exhibited higher efficacy in inhibiting the growth of tested phytopathogens, showing inhibitory indices of 60.0-93.6 % at 1.0 mg/mL. Chitosan derivatives with methyl and chlorine (Compound 10B and 10C) exhibited significant antibacterial activity against S. aureus (MIC = 31.2 mu g/mL), E. coli (MIC = 7.8 mu g/mL), and V. harveyi (MIC = 15.6 mu g/mL), respectively. The results of the cytotoxicity assay showed no observed cytotoxicity when the RAW 264.7 cells were incubated with the synthesized polysaccharide derivatives at the tested concentrations.
Funding OrganizationScience and Technology Specific Projects in Agricul-tural High-tech Industrial Demonstration Area of the Yellow River Delta ; National Natural Science Foundation of China ; 2022 Central Guiding Local Science and Technology Development Fund Project in Shandong Province
Indexed BySCI
Language英语
WOS KeywordRADICAL-SCAVENGING ACTIVITY ; ANTIOXIDANT ACTIVITY ; CHITOSAN DERIVATIVES ; ANTICANCER AGENTS ; DESIGN ; DPPH
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS IDWOS:001075112600001
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/32816
Collection海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Yantai Univ, Coll Life Sci, Yantai 264003, Peoples R China
3.China Univ Petr, Coll Chemisry & Chem Engn, Qingdao 266580, Peoples R China
4.Ludong Univ, Sch Resources & Environm Engn, Yantai 264025, Peoples R China
5.Shandong Saline Alkali Land Modern Agr Co, Dongying 257300, Peoples R China
Recommended Citation
GB/T 7714
Li, Qing,Yang, Yunhui,Li, Yijian,et al. Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,253:13.
APA Li, Qing.,Yang, Yunhui.,Li, Yijian.,Mi, Yingqi.,Ma, Xuanxuan.,...&Guo, Zhanyong.(2023).Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,253,13.
MLA Li, Qing,et al."Enhanced biological activities of coumarin-functionalized polysaccharide derivatives: Chemical modification and activity assessment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 253(2023):13.
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