Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver

	Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver
	Xiaohan Xu 1; Kyle L. Poulsen 2; Lijuan Wu 1; Shan Liu 3; Tatsunori Miyata 4; Qiaoling Song 3; Qingda Wei 5; Chenyang Zhao 1; Chunhua Lin 6; Jinbo Yang 1
发表期刊	Signal Transduction and Targeted Therapy
ISSN	2059-3635
卷号	7 期号:1
英文摘要	Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive and more susceptible to developing cirrhosis and hepatocellular carcinoma. Currently, lifestyle interventions are the most essential and effective strategies for preventing and controlling NAFL without the development of fibrosis. While there are still limited appropriate drugs specifically to treat NAFL/NASH, growing progress is being seen in elucidating the pathogenesis and identifying therapeutic targets. In this review, we discussed recent developments in etiology and prospective therapeutic targets, as well as pharmacological candidates in pre/clinical trials and patents, with a focus on diabetes, hepatic lipid metabolism, inflammation, and fibrosis. Importantly, growing evidence elucidates that the disruption of the gut–liver axis and microbe-derived metabolites drive the pathogenesis of NAFL/NASH. Extracellular vesicles (EVs) act as a signaling mediator, resulting in lipid accumulation, macrophage and hepatic stellate cell activation, further promoting inflammation and liver fibrosis progression during the development of NAFL/NASH. Targeting gut microbiota or EVs may serve as new strategies for the treatment of NAFL/NASH. Finally, other mechanisms, such as cell therapy and genetic approaches, also have enormous therapeutic potential. Incorporating drugs with different mechanisms and personalized medicine may improve the efficacy to better benefit patients with NAFL/NASH.
语种	英语
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32023
专题	中国科学院烟台海岸带研究所知识产出
作者单位	1.中国海洋大学 2.University of Texas Health Science Center 3.黑龙江省环境保护科学研究院 4.熊本大学 5.郑州大学 6.中国科学院烟台海岸带研究所
推荐引用方式 GB/T 7714	Xiaohan Xu,Kyle L. Poulsen,Lijuan Wu,et al. Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver[J]. Signal Transduction and Targeted Therapy,7(1).
APA	Xiaohan Xu.,Kyle L. Poulsen.,Lijuan Wu.,Shan Liu.,Tatsunori Miyata.,...&Jinbo Yang.
MLA	Xiaohan Xu,et al."Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver".Signal Transduction and Targeted Therapy 7.1