| Potential roles of FoxO in promoting longevity in larger Argopecten scallops | |
Wang, Yuan1,3; Lu, Xia1,4 ; Wang, Chunde1,2; Ning, Junhao1; Chen, Min1; Yuan, Ke1,3
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| 发表期刊 | AQUACULTURE
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| ISSN | 0044-8486 |
| 2022-12-15 | |
| 卷号 | 561页码:15 |
| 关键词 | Bivalve Argopecten scallops FoxO Longevity Larger size |
| DOI | 10.1016/j.aquaculture.2022.738690 |
| 英文摘要 | Bay scallops are commercially important bivalve species for fisheries and aquaculture in China, the USA, Peru and Chile, but their small size, short lifespan (<14 months) and serious inbreeding depression restrict the sustainable development of their aquaculture. Compared with bay scallops, some interspecific hybrids of bay scallops and Peruvian scallops exhibit longer lifespans and significantly larger sizes, which may result from the longevity genes of Peruvian scallops, which have lifespans of 7-10 years. The FoxO transcription factor integrates signals from different longevity-related pathways that play a crucial role in aging and longevity in terrestrial model organisms. However, limited information is available on its roles in the longevity of marine animals. Here, we extended this paradigm using Peruvian scallops and bay scallops, which have distinct lifespans. Cloning and sequence analysis of the FoxO ORFs (ApFoxO and AiFoxO) revealed 22 synonymous, 7 nonsynonymous SNPs and two InDels between the two species. The amino acid variations (Q27 and E28) near the AKT phosphorylation site (T21) may affect the activities of ApFoxO for longevity. Nutrient restriction could extend lifespan in terrestrial model organisms, and the expression of ApFoxO and AiFoxO both significantly increased under nutrient restriction, but the response in bay scallops was faster and more robust than that in Peruvian scallops. Furthermore, ionizing radiation caused significantly lower mortality and higher FoxO expression in Peruvian scallops. These results suggested that FoxO may play a protective role in longevity through nutrient availability and DNA repair for genomic stability. The significantly decreased expression of CAT and Mn-SOD and the increased beta-GAL activity (a marker for senescence) after FoxO downregulation suggested that FoxO may contribute to longevity by controlling ROS with its antioxidase activity. The results of our work provide the basis for understanding the role of FoxO in longevity in scallops and its potential as a biomarker for selecting larger hybrids to benefit scallop aquaculture. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | INSULIN SIGNALING PATHWAY ; CALORIC RESTRICTION ; TRANSCRIPTION FACTORS ; EXPRESSION PROFILE ; BAY SCALLOP ; AKT ; METABOLISM ; DAF-16 ; LIFE ; RESISTANCE |
| 研究领域[WOS] | Fisheries ; Marine & Freshwater Biology |
| WOS记录号 | WOS:000848310800005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/31653 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Lu, Xia |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Shandong, Peoples R China 2.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.17 Chunhui Rd, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yuan,Lu, Xia,Wang, Chunde,et al. Potential roles of FoxO in promoting longevity in larger Argopecten scallops[J]. AQUACULTURE,2022,561:15. |
| APA | Wang, Yuan,Lu, Xia,Wang, Chunde,Ning, Junhao,Chen, Min,&Yuan, Ke.(2022).Potential roles of FoxO in promoting longevity in larger Argopecten scallops.AQUACULTURE,561,15. |
| MLA | Wang, Yuan,et al."Potential roles of FoxO in promoting longevity in larger Argopecten scallops".AQUACULTURE 561(2022):15. |
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