| A fas apoptotic inhibitory molecule from Ruditapes philippinarum: Investigation on molecular characterization and functional analysis | |
Chen, Lizhu1; Li, Bin1; Hu, Shunxin1; Qiao, Ruiguang1; Sun, Chunxiao1; Yang, Dinglong2,3,4
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| 发表期刊 | FISH & SHELLFISH IMMUNOLOGY
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| ISSN | 1050-4648 |
| 2020-09-01 | |
| 卷号 | 104页码:133-140 |
| 关键词 | FAIM Ruditapes philippinarum NF-kappa B Apoptosis |
| DOI | 10.1016/j.fsi.2020.05.058 |
| 通讯作者 | Yang, Dinglong(dlyang@yic.ac.cn) |
| 英文摘要 | In the present study, a fas apoptotic inhibitory molecule (FAIM) was identified from Ruditapes philippinarum (designated as RpFAIM). Multiple alignments and phylogenetic analysis strongly suggested that RpFAIM was a new member of the FAIMs family. The RpFAIM transcripts were constitutively expressed in a wide range of tissues, and dominantly expressed in hemocytes. After V. anguillarum or M. luteus challenge, the expression level of RpFAIM transcripts was significantly induced and reached the maximum level at 6 h and 24 h, respectively. Knockdown of RpFAIM down-regulated the transcript levels of NF-kappa B signaling genes (e.g. RpIKK, RpI kappa B, RpNF-kappa B). The results were roughly similar to those under bacterial stimulation. Moreover, RpFAIM primarily localized in the cell cytoplasm, and its over-expression inhibited the apoptosis of HeLa cells. These results revealed that RpFAIM perhaps regulated the NF-kappa B signaling pathways positively, which provided a better understanding of RpFAIM in innate immunity. |
| 资助机构 | Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | MEDIATED APOPTOSIS ; CASPASE ACTIVATION ; AKT ACTIVATION ; LONG FORM ; EXPRESSION ; FAIM ; DISEASE |
| 研究领域[WOS] | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS记录号 | WOS:000564750000003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/28528 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 支撑部门_中国科学院牟平海岸带环境综合试验站 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Yang, Dinglong |
| 作者单位 | 1.Shandong Marine Resource & Environm Res Inst, Yantai 264006, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Shandong, Peoples R China 4.Chinese Acad Sci, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Lizhu,Li, Bin,Hu, Shunxin,et al. A fas apoptotic inhibitory molecule from Ruditapes philippinarum: Investigation on molecular characterization and functional analysis[J]. FISH & SHELLFISH IMMUNOLOGY,2020,104:133-140. |
| APA | Chen, Lizhu,Li, Bin,Hu, Shunxin,Qiao, Ruiguang,Sun, Chunxiao,&Yang, Dinglong.(2020).A fas apoptotic inhibitory molecule from Ruditapes philippinarum: Investigation on molecular characterization and functional analysis.FISH & SHELLFISH IMMUNOLOGY,104,133-140. |
| MLA | Chen, Lizhu,et al."A fas apoptotic inhibitory molecule from Ruditapes philippinarum: Investigation on molecular characterization and functional analysis".FISH & SHELLFISH IMMUNOLOGY 104(2020):133-140. |
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| A fas apoptotic inhi（2447KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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