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Critical target identification and human health risk ranking of metal ions based on mechanism-driven modeling 期刊论文
CHEMOSPHERE, 2022, 卷号: 301, 页码: 9
作者:  Wang, Xiaoqing;  Teng, Yuefa;  Ji, Chenglong;  Wu, Huifeng;  Li, Fei
收藏  |  浏览/下载:249/0  |  提交时间:2022/07/26
Metal ions  p53  QSAR  Genetic toxicity  Human health risk  
Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations 期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 卷号: 783, 页码: 9
作者:  Sun, Tao;  Zhan, Junfei;  Li, Fei;  Ji, Chenglong;  Wu, Huifeng
浏览  |  Adobe PDF(1588Kb)  |  收藏  |  浏览/下载:643/300  |  提交时间:2021/10/20
Microplastics  Aquatic organisms  Genotoxicity  Meta-analysis  Environmentally relevant concentrations  
Stress responses in expressions of microRNAs in mussel Mytilus galloprovincialis exposed to cadmium 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 卷号: 212, 页码: 8
作者:  Yu, Deliang;  Peng, Zheng;  Wu, Huifeng;  Zhang, Xiaoying;  Ji, Chenglong;  Peng, Xiao
浏览  |  Adobe PDF(2857Kb)  |  收藏  |  浏览/下载:494/144  |  提交时间:2021/06/07
Mytilus galloprovincialis  MicroRNAs  Cadmium  Toxicological effects  
Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP) 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 卷号: 205, 页码: 9
作者:  Wang, Xiaoqing;  Li, Fei;  Liu, Jialin;  Ji, Chenglong;  Wu, Huifeng
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Triphenyl phosphate (TPP)  Multi-omit approach  Hepatotoxicity  
Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate 期刊论文
MARINE POLLUTION BULLETIN, 2020, 卷号: 151, 页码: 110838
作者:  Meng, Xiangjing;  Li, Fei;  Wang, Xiaoqing;  Liu, Jialin;  Ji, Chenglong;  Wu, Huifeng
浏览  |  Adobe PDF(2503Kb)  |  收藏  |  浏览/下载:679/295  |  提交时间:2020/07/08
ORGANOPHOSPHATE FLAME RETARDANTS  IN-VITRO  PRISTINE GRAPHENE  OXIDATIVE STRESS  MARINE MUSSEL  CAGED MUSSELS  OXIDE  TOXICITY  NANOPARTICLES  NANOMATERIALS  
典型有机磷酸酯阻燃剂有害结局路径(AOP)的机制探索 期刊论文
海岸科学, 2019, 卷号: 6, 期号: 1, 页码: 16-21
作者:  王晓晴;  李斐;  吉成龙;  吴惠丰
Adobe PDF(509Kb)  |  收藏  |  浏览/下载:307/63  |  提交时间:2021/11/11
有机磷酸酯阻燃剂(OPFRs)  毒理效应  计算毒理学  有害结局路径(AOP)  
磷酸三苯酯(TPP)和磷酸三(2-氯异丙基)酯(TCPP)诱导人胚肾细胞HEK293凋亡的机制研究 期刊论文
生态毒理学报, 2019, 卷号: 14, 期号: 5, 页码: 123-132
作者:  王晓晴;  刘佳琳;  李斐;  曹天贵;  吴惠丰;  孟祥敬;  吉成龙
浏览  |  Adobe PDF(7902Kb)  |  收藏  |  浏览/下载:591/269  |  提交时间:2020/07/08
有机磷酸酯阻燃剂  磷酸三(2-氯异丙基)酯(Tcpp)  磷酸三苯酯(Tpp)  肾细胞  细胞凋亡  Organophosphate Flame Retardant  Tris (2-chloroisopropyl) Phosphate (Tcpp)  Triphenyl Phosphate(Tpp)  Kidney Cell  Apoptosis  
石墨烯与抑癌基因p53 DNA片段相互作用的分子模拟与光谱学验证 期刊论文
生态毒理学报, 2017, 卷号: 12, 期号: 3, 页码: 243-250
作者:  吴惠丰;  张明兴;  李斐;  曹天贵;  李雪花;  赵建民
收藏  |  浏览/下载:159/0  |  提交时间:2020/07/07
p53-DNA  graphene(G)  p53-DNA  binding interaction  molecular dynamics simulations  spectroscopic methods  石墨烯  相互作用  分子动力学模拟  光谱法  
典型持久性有机污染物与抑癌基因相互作用的分子模拟与验证 期刊论文
科学通报, 2015, 卷号: 60, 期号: 19, 页码: 1804-1809
作者:  吴惠丰;  曹璐璐;  李斐;  李雪花;  赵建民
浏览  |  Adobe PDF(1577Kb)  |  收藏  |  浏览/下载:695/313  |  提交时间:2016/12/15
持久性有机污染物  P53  2  分子模拟  2'  光谱法  4  4'-四溴联苯醚(Bde-47)  
Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study 期刊论文
TOXICOLOGY LETTERS, 2015, 卷号: 232, 期号: 2, 页码: 533-541
作者:  Li, Fei;  Cao, Lulu;  Li, Xuehua;  Li, Na;  Wang, Zijian;  Wu, Huifeng;  Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
浏览  |  Adobe PDF(2093Kb)  |  收藏  |  浏览/下载:801/288  |  提交时间:2015/07/31
Organophosphate Flame Retardants (Opfrs)  P53  Docking  Quantitative Structure-activity Relationship (Qsar)  Binding Affinity  Partial Least Squares (Pls)