YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo
Yu, FB; Gao, M; Li, M; Chen, LX; Chen, LX (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
2015-09-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume63Pages:93-101
Contribution Rank[Yu, Fabiao; Gao, Min; Li, Meng; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
AbstractIntracellular reactive sulfur species play important roles in physiological and pathological processes. Emerging evidences suggest that sulfane sulfur instead of H2S is the actual signaling molecule in these processes. Sulfane sulfur can be generated as a result of the reaction between O-2 and H2S in mitochondria. Therefore, we develop a near-infrared mitochondria-targeting probe that allows multiresponse to O-2 and H2SO successively for investigating this biosynthetic reaction. The probe exhibits highly selective fluorescent response to O-2 and H2SO successively in presence of potential biological interferants. Fluorescent imaging studies and flow cytometry analysis of RAW264.7 cells elaborate that the probe can be used to reveal the continuous process of O-2 burst and H2SO production in situ and in real-time. The mitochondria isolation indicates that the probe can specifically localize in mitochondria. Finally, the fluorescent probe has been successfully applied to detect O-2 and H2Sn in mice. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordFluorescent Probe Image Analysis Hydrogen Polysulfides Superoxide Anion Near-infrared
Department中科院海岸带环境过程与生态修复重点实验室
DOI10.1016/j.biomaterials.2015.06.007
Indexed BySCI
WOS KeywordDIFFERENT EMISSION CHANNELS ; REACTIVE OXYGEN ; LIVING CELLS ; OXIDATIVE STRESS ; LIVE CELLS ; HYPOCHLOROUS ACID ; SULFANE SULFUR ; SULFIDE ; PEROXYNITRITE ; H2S
SubtypeArticle
Language英语
WOS Research AreaEngineering ; Materials Science
WOS IDWOS:000357910400009
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Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/9271
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorChen, LX (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
Recommended Citation
GB/T 7714
Yu, FB,Gao, M,Li, M,et al. A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo[J]. BIOMATERIALS,2015,63:93-101.
APA Yu, FB,Gao, M,Li, M,Chen, LX,&Chen, LX .(2015).A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo.BIOMATERIALS,63,93-101.
MLA Yu, FB,et al."A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo".BIOMATERIALS 63(2015):93-101.
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