A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo
Yu, FB; Gao, M; Li, M; Chen, LX; Chen, LX (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
发表期刊BIOMATERIALS
ISSN0142-9612
2015-09-01
卷号63页码:93-101
关键词Fluorescent Probe Image Analysis Hydrogen Polysulfides Superoxide Anion Near-infrared
DOI10.1016/j.biomaterials.2015.06.007
产权排序[Yu, Fabiao; Gao, Min; Li, Meng; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
作者部门中科院海岸带环境过程与生态修复重点实验室
英文摘要Intracellular reactive sulfur species play important roles in physiological and pathological processes. Emerging evidences suggest that sulfane sulfur instead of H2S is the actual signaling molecule in these processes. Sulfane sulfur can be generated as a result of the reaction between O-2 and H2S in mitochondria. Therefore, we develop a near-infrared mitochondria-targeting probe that allows multiresponse to O-2 and H2SO successively for investigating this biosynthetic reaction. The probe exhibits highly selective fluorescent response to O-2 and H2SO successively in presence of potential biological interferants. Fluorescent imaging studies and flow cytometry analysis of RAW264.7 cells elaborate that the probe can be used to reveal the continuous process of O-2 burst and H2SO production in situ and in real-time. The mitochondria isolation indicates that the probe can specifically localize in mitochondria. Finally, the fluorescent probe has been successfully applied to detect O-2 and H2Sn in mice. (C) 2015 Elsevier Ltd. All rights reserved.
文章类型Article
收录类别SCI
语种英语
关键词[WOS]DIFFERENT EMISSION CHANNELS ; REACTIVE OXYGEN ; LIVING CELLS ; OXIDATIVE STRESS ; LIVE CELLS ; HYPOCHLOROUS ACID ; SULFANE SULFUR ; SULFIDE ; PEROXYNITRITE ; H2S
研究领域[WOS]Engineering ; Materials Science
WOS记录号WOS:000357910400009
引用统计
被引频次:144[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/9271
专题中国科学院海岸带环境过程与生态修复重点实验室
通讯作者Chen, LX (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
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Yu, FB,Gao, M,Li, M,et al. A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo[J]. BIOMATERIALS,2015,63:93-101.
APA Yu, FB,Gao, M,Li, M,Chen, LX,&Chen, LX .(2015).A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo.BIOMATERIALS,63,93-101.
MLA Yu, FB,et al."A dual response near-infrared fluorescent probe for hydrogen polysulfides and superoxide anion detection in cells and in vivo".BIOMATERIALS 63(2015):93-101.
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