In vivo assessment of the oxidative and apoptotic potential of perfluorooctanoic acid

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	In vivo assessment of the oxidative and apoptotic potential of perfluorooctanoic acid
	Yang, Shaoli(1); Su, Zhen(1); Yang, S. (yshl2004@163.com)
发表期刊	BioTechnology: An Indian Journal
ISSN	0974-7435
	2013
卷号	8 期号:1 页码:90-95
关键词	Anti-oxidative Enzymes - Cell Apoptosis - Expression Profile - Lipid Peroxidation - Perfluorooctanoic Acid - Super Oxide Dismutase - Zebrafish - Zebrafish Embryos
产权排序	(1) Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China
作者部门	海岸带生物学与生物资源利用所重点实验室
英文摘要	Perfluorooctanoic acid (PFOA) is an organic pollutant abundant in the environment, and the potential toxicity of which is causing great concern. The oxidative and apoptotic potential of PFOA was assessed in a shortterm in vivo zebrafish assay in this study. Activities of antioxidative enzymes, including superoxide dismutase and catalase, were significantly altered in PFOA-treated embryos. Lipid peroxidation was increased with exposure to higher concentrations. Expression profiles of certain genes related to cellular apoptosis were then investigated. The expression of p53 and Baxwere partially increased, which could be linked to PFOA-induced cell apoptosis in zebrafish. The overall results demonstrated that PFOA could induce oxidative stress and alter the expression of genes involve in apoptosis, resulting in oxidative damagesin zebrafish embryos.
文章类型	期刊论文
收录类别	EI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/8845
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Yang, S. (yshl2004@163.com)
推荐引用方式 GB/T 7714	Yang, Shaoli,Su, Zhen,Yang, S. . In vivo assessment of the oxidative and apoptotic potential of perfluorooctanoic acid[J]. BioTechnology: An Indian Journal,2013,8(1):90-95.
APA	Yang, Shaoli,Su, Zhen,&Yang, S. .(2013).In vivo assessment of the oxidative and apoptotic potential of perfluorooctanoic acid.BioTechnology: An Indian Journal,8(1),90-95.
MLA	Yang, Shaoli,et al."In vivo assessment of the oxidative and apoptotic potential of perfluorooctanoic acid".BioTechnology: An Indian Journal 8.1(2013):90-95.